Method for organizing the assembly of collagen fibers and compositions formed therefrom
AssigneeDePuy Products, Inc.
InventorsHugo Pedrozo, Mark Shuster
Life of this patent
Estimating the term…
Abstract
The present invention provides a protein polymer material and a method for preparing the protein polymer material involving applying an energy such as electrical energy or gravitational energy to a protein to cause the protein to assemble in a controlled arrangement. The protein used in this method may be any suitable fibrillar protein capable of self-assembling.
Claims21
A method for preparing a polymer matrix, comprising:
- providing a composition comprising a monomer;
- and
- assembling a polymer matrix from the monomer in the presence of an electrical force.
The method of claim 13, wherein the monomer composition comprises collagen extracted from a naturally occurring extracellular matrix.
The method of claim 16 further comprising the step of adding a solution comprising (NH4)2SO4.
A method for preparing an ordered collagen matrix, said method comprising the steps of
- providing a solution of collagen fibers;
- centrifuging the collagen fiber solution under vacuum at a centrifugal force of about 10,000×g to about 100,000×g, to form a polymer matrix wherein the collagen fibers are assemble at an angle defined by the centrifugal force.
Dependencies are inferred from the claim text.