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US 2006/0135620 A1Published application
Novel compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
AssigneeNovaremed Limited
InventorEliahu Kaplan
Life of this patent
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Abstract
The present invention provides compounds, pharmaceutical compositions and methods for treating, immuno-allergical diseases, autoimmune diseases, and organ or tissue rejection following transplantation.
Claims140
A compound represented by the structure of formula I:
- wherein
- the dotted line represents a single or a double bond;
- R1 and R2 are the same or different, and independently of each other represent —CH2OH, —CH2OR4, —CH(OH)CH3, —CH(OR4)CH3, or a group represented by the formula
- wherein
- R4 is a linear or branched C1-C4 alkyl;
- R5 is H, OH or OR6 wherein R6 is a linear or branched C1-C4 alkyl;
- A-B is a group represented by the formula:
- X is O, —CH2O, —CH2CH2O, —CH(CH3)CH2O, or —CH2CH(CH3)O;
- Z is —CH2CH2O, —CH(CH3)CH2O, or —CH2CH(CH3)O;
- m is an integer of 0 or 1;
- and
- n is an integer of 0-50;
- and salts or hydrates thereof.
10 more elements
A compound represented by the structure of formula II:
- wherein
- the dotted line represents a single or a double bond;
- R5 and R5′ are independently of each other H, OH or OR6 wherein R6 is a linear or branched C1-C4 alkyl;
- X is O, —CH2O, —CH2CH2O, —CH(CH3)CH2O, or —CH2CH(CH3)O;
- Z is —CH2CH2O, —CH(CH3)CH2O, or CH2CH(CH3)O;
- m is an integer of o or 1;
- and
- n is an integer of 0-50;
- and salts or hydrates thereof.
6 more elements
A compound represented by the structure of formula III:
- wherein
- the dotted line represents a single or a double bond;
- R5 and R5′ are independently of each other H, OH or OR6 wherein R6 is a linear or branched C1-C4 alkyl;
- Z is —CH2CH2O, —CH(CH3)CH2O, or CH2CH(CH3)O;
- n is an integer of 0-50;
- and salts or hydrates thereof.
3 more elements
A compound represented by the structure of formula IV:
- wherein
- the dotted line represents a single or a double bond;
- R5 and R5′ are independently of each other H, OH or OR6 wherein R6 is a linear or branched C1-C4 alkyl;
- n is an integer of 0-50;
- and salts or hydrates thereof.
2 more elements
A compound represented by the structure of formula I:
- wherein
- the dotted line represents a single or a double bond;
- R1 and R2 are the same or different, and independently of each other represent —CH2OH, —CH2OR4, —CH(OH)CH3, —CH(OR4)CH3, or a group represented by the formula
- wherein
- R4 is a linear or branched C1-C4 alkyl;
- R5 is H, OH or OR6 wherein R6 is a linear or branched C1-C4 alkyl;
- A-B is a group represented by the formula:
- X is O, —CH2O, —CH2CH2O, —CH(CH3)CH2O, or —CH2CH(CH3)O;
- Z is —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O;
- m is 1;
- and
- n is an integer of 1-500;
- and salts or hydrates thereof.
10 more elements
A compound represented by the structure of formula II:
- wherein
- the dotted line represents a single or a double bond;
- R5 and R5′ are independently of each other H, OH or OR6 wherein R6 is a linear or branched C1-C4 alkyl;
- X is O, —CH2O, —CH2CH2O, —CH(CH3)CH2O, or —CH2CH(CH3)O;
- Z is —CH2CH2O, —CH(CH3)CH2O, or —CH2CH(CH3)O;
- m is 1;
- and
- n is an integer of 1-500;
- and salts or hydrates thereof.
6 more elements
A compound represented by the structure of formula III:
- wherein
- the dotted line represents a single or a double bond;
- R5 and R5′ are independently of each other H, OH or OR6 wherein R6 is a linear or branched C1-C4 alkyl;
- Z is —CH2CH2O, —CH(CH3)CH2O, or —CH2CH(CH3)O;
- n is an integer of 1-500;
- and salts or hydrates thereof.
3 more elements
A compound represented by the structure of formula IV:
- wherein
- the dotted line represents a single or a double bond;
- R5 and R5′ are independently of each other H, OH or OR6 wherein R6 is a linear or branched C1-C4 alkyl;
- n is an integer of 1-500;
- and salts-or hydrates thereof.
2 more elements
A compound of Formula A:
- wherein R is a polyalkylene glycol polymer having n units, where n is an integer from 1-100.
A compound of Formula B:
- wherein R is a polyalkylene glycol polymer having n units, where n is an integer from 1-100.
A compound of Formula C:
- wherein R is a polyalkylene glycol polymer having n units, where n is an integer from 1-100.
A compound of Formula D:
- wherein R is a polyalkylene glycol polymer having n units, where n is an integer from 1-100.
A compound of Formula E:
- wherein R is a polyalkylene glycol polymer having n units, where n is an integer from 1-100.
A compound of Formula F:
- wherein R is a polyalkylene glycol polymer having n units, where n is an integer from 1-100.
Dependencies are inferred from the claim text.