Medicine comprising a thiourea for use as depigmenting agent or anti-mutagenic and anti-carcinogenic agent

A pharmaceutical composition comprising a pharmaceutically effective amount of at least one thiourea of the following general formula I:

• in which:
• n is an integer between 1 and 12,
• m is an integer between 1 and 12,
• R1, R2, R3 and R4 represent, independently of one another, a hydrogen atom, a C1-C6 alkyl group, or an aryl group,
• or at least one of its monoxide or dioxide derivatives of the following general formulae IIa, IIb and III:
• in which R1, R2, R3, R4, m and n are as defined above,
• or their mixtures, and a pharmaceutically acceptable carrier therefor.

A depigmenting cosmetic composition comprising a depigmenting effective amount of at least one thiourea of the following general formula I:

• in which:
• n is an integer between 1 and 12,
• m is an integer between 1 and 12,
• R1, R2, R3 and R4 represent, independently of one another, a hydrogen atom, a C1-C6 alkyl group or an aryl group,
• or at least one of its monoxide or dioxide derivatives of the following general formulae IIa, IIb and III:
• in which R1, R2, R3, R4, m and n are as defined above, or their mixtures, and a cosmetically acceptable carrier therefor.

A thiourea of the following general formula I:

• in which:
• n is an integer between 1 and 12,
• m is an integer between 1 and 12,
• R1, R2, R3 and R4 represent, independently of one another, a hydrogen atom, a C1-C6 alkyl group, or an aryl group,
• or at least one of its monoxide or dioxide derivatives of the following general formulae IIa, IIb and III:
• in which R1, R2, R3, R4, m and n are as defined above, with the exception of N, N-di(methylsulphinylbutyl)thiourea and dicheirolin thiourea.