Process for producing optically active flurbiprofen
AssigneeNagase & Co., Ltd.
InventorsShunji Kamiyama, Kazuto Yoshida, Yasuo Chikusa, Jun Matsumoto, Keisuke Matsuyama
Life of this patent
Estimating the term…
Abstract
The present invention provides a method for producing optically active flurbiprofen. The method of the present invention includes mixing racemic flurbiprofen and (S)- or (R)-3-methyl-2-phenylbutylamine in an organic solvent to produce a diastereomeric salt; and treating the diastereomeric salt with an acid in a second solvent. In the method of the present invention, flurbiprofen having a desired absolute configuration can be obtained very efficiently without repeating the procedure for optical resolution a plurality of times.
Claims10
A method for producing optically active flurbiprofen which comprises:
- mixing racemic flurbiprofen and (S)- or (R)-3-methyl-2-phenylbutylamine in an organic solvent to produce a diastereomeric salt;
- and
- treating the diastereomeric salt with an acid in a second solvent.
A diastereomeric salt obtained by mixing (S)- or (R)-3-methyl-2-phenylbutylamine and racemic flurbiprofen in an organic solvent.
A diastereomeric salt represented by the following formula (I):
A diastereomeric salt represented by the following formula (II):
Dependencies are inferred from the claim text.