Aromatic compositions for the inhibition of exoprotein production from gram positive bacteria

A douche formulation for inhibiting the production of exoprotein from Gram positive bacteria comprising a vaginal cleansing formulation comprising a pharmaceutically acceptable carrier, an effective amount of a first active ingredient, and an effective amount of a second active ingredient the first active ingredient having the general formula:

• wherein R1 is selected from the group consisting of H,
• and salts thereof;
• R5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety;
• R6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety;
• R7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety;
• R8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms;
• R2, R3, and R4 are independently selected from the group consisting of H, OH, COOH, and —C(O)R9;
• R9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety, wherein the second active ingredient is myreth-3-myristate, and wherein the first active ingredient and the second active ingredient are effective in inhibiting the production of exoprotein from Gram positive bacteria.

A method of inhibiting the production of exoprotein from Gram positive bacteria comprising exposing said Gram positive bacteria to an effective amount of a first active ingredient and a second active ingredient, said first active ingredient having the general formula:

• wherein R1 is selected from the group consisting of H,
• and salts thereof;
• R5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety;
• R6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety;
• R7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety;
• R8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms;
• R2, R3, and R4 are independently selected from the group consisting of H, OH, COOH, and —C(O)R9;
• R9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety, and said second active ingredient is myreth-3-myristate.