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US 2006/0135604 A1Published application
Pharmaceutical compositions of isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid and methods of use
AssigneeMediciNova, Inc.
InventorsKenneth Locke, David Roe
Life of this patent
Estimating the term…
Abstract
A pharmaceutical composition comprising a compound of formula (1) in polymorphic crystalline Form A: together with a pharmaceutically acceptable carrier or excipient, wherein the compound of formula (1) is present in polymorphic Form A (see, e.g., FIG. 6) substantially free of other polymorphic forms.
Claims12
Isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid, prepared by the method of:
- dissolving 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid in ethanol, adding water and cooling the resulting mixture first to about 10-15° C. and second to about 5-10° C., adding more water, agitating the resulting mixture at about 5-10° C., and isolating the orthorhombic crystals of 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid.
Isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid, prepared by the method of:
- dissolving 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid in aqueous ethanol, agitating the resulting suspension at 20-25° C. for 15-60 minutes and then cooling to 5-10° C. for an additional period of 1-4 hours, adding water to this suspension and agitating the mixture at 5-10° C. for an additional 1-4 hours, and isolating the orthorhombic crystals of 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid.
Dependencies are inferred from the claim text.