Amorphous form of a drug
OwnerGeoff Zhanginventor
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Abstract
Substantially amorphous atrasentan hydrochloride, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
Claims8
Substantially amorphous atrasentan hydrochloride.
A composition made with or comprising an excipient and substantially amorphous atrasentan hydrochloride.
A method for treating prostate cancer in a human comprising administering thereto a therapeutically effective amount of substantially amorphous atrasentan hydrochloride.
A method for treating nociceptionin a human comprising administering thereto a therapeutically effective amount of substantially amorphous atrasentan hydrochloride.
A method for treating bone pain associated with bone cancer in a human comprising administering thereto a therapeutically effective amount of substantially amorphous atrasentan hydrochloride.
A method for inhibiting bone metastases in a human having prostate cancer that has metastasized to bone comprising administering thereto a therapeutically effective amount of substantially amorphous atrasentan hydrochloride.
A process for making substantially amorphous atrasentan hydrochloride, the process comprising the acts of:
- providing a mixture comprising the atrasentan or the solvate thereof and solvent, wherein the atrasentan is completely dissolved in the solvent;
- and
- removing the solvent at such a rate that substantially amorphous atrasentan hydrochloride forms;
- and
Dependencies are inferred from the claim text.