Modulators of CRTH2 activity

A compound having the formula:

• wherein:
• A is
• R is H, a C1-C3 alkyl, optionally independently substituted with one or more halogen;
• n is 1, 2, 3 or 4;
• R1 is H;
• a C1-C6 alkyl, optionally independently substituted with one or more —OH, —NH2, or halogen;
• or a C1-C6 alkenyl optionally independently substituted with one or more —OH, —NH2 or halogen;
• R2 is H;
• a C1-C6 alkyl, optionally independently substituted with one or more halogen;
• or a C1-C6 alkenyl optionally independently substituted with one or more halogen;
• R3 is a halogen;
• —CN;
• —OH;
• —SH;
• a C1-C3 alkyl, optionally independently substituted with one or more halogen;
• —OR3A;
• —SR3A;
• —SOR3A;
• or —S(O)2R3A, wherein R3A is a C1-C3 alkyl, optionally independently substituted with one or more halogen;
• m is 0, 1, 2, 3, 4, or 5;
• R4 is H or a halogen;
• R5 is H or a halogen;
• Y and Y′ are both H or Y and Y′ taken together are O or Y and Y′ taken together are S;
• X is O, S, or —NR6, wherein R6 is a C1-C3 alkyl, optionally independently substituted with one or more halogen;
• and
• R7 is —OH, —OR7A;
• or R7A, wherein R7A is:
• H or a C1 to C6 (C1, C2, C3, C4, C5, C6) alkyl, alkenyl, alkynyl, aryl, cycloalkyl, or arylalkyl optionally independently substituted with one or more halogen —OH, —C(O)OH, or —NH3;
• provided that if A is
• n is 1, R1 is H, Y is O, R2 is —CH3, R4 is H, R5 is H and R is —CH3, then R3 is not:
• Cl, H, F or —CF3;
• further provided that if A is
• n is 1, R1 is H, Y is O, R2 is —CH3, R4 is H, R5 is H, R is H, then R3 is not H;
• further provided that
• when A is
• n is 1, R1 is H, Y is O, R2 is —CH3, R4 is F, R5 is H, R is —CH3, R3 is not H;
• and further provided that when A is
• n is 1, R1 is H, Y is O, R2 is —CH3, R4 is H, R5 is H, then R is not H.