Method and compounds for promoting healing and reducing inflammation
OwnerNikolay Sapronov, Levon Piotrovsky +1inventors
InventorsNikolay Sapronov, Levon Piotrovsky, Luidmila Gavrovskaya
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Abstract
This invention relates to methods of promoting healing and reducing inflammation, and compositions therefore. In particular, the invention relates to the use of 1,3-dialkyl-4,5-bis(N-methylcarbamoyl)imidazolium salts to promote wound healing and to reduce inflammation. Novel compounds and compositions are also provided. In one preferred embodiment the invention provides a method of treatment of myocardial infarction.
Claims45
A method of promoting tissue repair or wound healing, comprising the step of administering an effective amount of a 1,3-dialkyl-4,5-bis (optionally N-substituted carbamoyl)imidazolium salt to a subject in need of such treatment.
A compound of formula I
- in which R1 and R2 are the same or different, and each is selected from the group consisting of hydrogen and a linear or branched alkyl group of 1 to 6 carbon atoms, which may optionally be substituted by an amino, substituted or unsubstituted aminomethyl, nitro, hydroxyl, hydrogen, carboxy, or carboxylic acid amide group;
- R3 and R4 are the same or different, and each is a substituted or unsubstituted linear or branched alkyl group of 1 to 6 carbon atoms;
- and
- X− is a pharmaceutically acceptable inorganic or organic anion selected from the group consisting of chloride, bromide, iodide, sulphate, nitrate, phosphate, perchlorate, formate, acetate, fumarate, malate, malonate, citrate, benzoate, salicylate, benzenesulphonate, methylsulphonate, p-toluenesulphonate, gentisate, and naphthalene-8-sulphonate,
- with the proviso that when X− is benzenesulphonate, R1 is hydrogen and R2 is methyl, R3 and R4 are not methyl or ethyl.
A method of promoting tissue repair, promoting wound healing or reducing inflammation in a subject, comprising administering to said subject a 1,3-dialkyl-4,5-bis (optionally N-substituted carbamoyl)imidazolium salt in an amount effective to promote tissue repair, promote wound healing or reduce inflammation in said subject.
45-50. (canceled)
Dependencies are inferred from the claim text.