Compounds and methods for thiol-containing compound efflux and cancer treatment
AssigneeNational Jewish Medical and Research Center
InventorsBrian Day, Remy Kachadourian
Life of this patent
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Abstract
Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis, cancer and/or another condition responsive to stimulation of thiol-containing compound transport.
Claims50
A compound of the formula:
- wherein R1 is an optionally substituted heteroaryl;
- where R4′ is hydrogen;
- and
- each of R2′, R3′, R5′ and R6′ is independently hydrogen or —ORc, where Rc is hydrogen or a hydroxy protecting group and wherein at least one of R2′, R3′, R5′, or R6′ is —OH.
A method comprising:
- identifying a subject having or at risk of developing cancer;
- contacting one or more cells with an agent to increase transport of at least one thiol-containing compound;
- modulating secretion of thiol-containing compound(s) from the cell;
- contacting one or more cells with an anti-cancer treatment;
- and
- attenuating the onset or progression of the cancer.
A method comprising:
- identifying a subject having or at risk of developing cancer;
- contacting one or more cells with a composition for inducing transport of at least one thiol-containing compound;
- contacting one or more cells with an anti-cancer agent;
- and
- attenuating the onset or progression of the cancer.
A kit for treating a subject having or at risk of developing cancer comprising:
- at least one delivery lumen;
- a first agent delivered from a delivery lumen wherein the first agent comprises an agent capable of increasing transport of thiol-containing compounds;
- and
- at least a second agent delivered from a delivery lumen wherein the second agent comprises an anti-cancer agent.
The kit of claim 51, wherein the agent capable of increasing transport of thiol-containing compounds comprises a flavone or a chalcone.
Dependencies are inferred from the claim text.