Imidazolidine derivatives
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsKazutaka Tachibana, Haruhiko Sato, Masateru Ohta, Mitsuaki Nakamura, Takuya Shiraishi, Ikuhiro Imaoka, Hitoshi Yoshino, Masahiro Nagamuta, Hiromitsu Kawata
Life of this patent
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Abstract
The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, each represent a hydrogen atom, or a linear or branched C1-C6 alkyl group, or a salt, a prodrug or a solvate thereof, as well as a drug, a pharmaceutical composition containing the compound, and the like.
Claims13
A compound represented by formula (I):
- wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, each represent a hydrogen atom or a linear or branched C1-C6 alkyl group, or a salt, a prodrug or a solvate thereof.
A compound represented by formula (II) or (II-a):
- wherein n is an integer selected from 1 to 20;
- Ra and Rb, which may be the same or different, are each selected from the group consisting of a linear or branched C1-C6 alkyl group substituted with one or more W1, a linear or branched C1-C6 alkylcarbonyl group which may be substituted with one or more W1, an arylcarbonyl group which may be substituted with one or more W2, a linear or branched C1-C6 alkoxycarbonyl group which may be substituted with one or more W1, an aryloxycarbonyl group which may be substituted with one or more W2, a linear or branched C1-C6 alkylaminocarbonyl group which may be substituted with one or more W1, a linear or branched C1-C6 dialkylaminocarbonyl group which may be substituted with one or more W1, a linear or branched C1-C6 alkylsulfonyl group which may be substituted with one or more W1, an arylsulfonyl group which may be substituted with one or more W2, and R1 and R2;
- or
- Ra and Rb may be joined together to form a group ═CH—W3;
- W1 is a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 alkylthio group, a linear or branched C1-C6 alkylsulfinyl group, a linear or branched C1-C6 alkylsulfonyl group, an aryl group which may be substituted with one or more W2, an aryloxy group which may be substituted with one or more W2, or a C1-C3 aralkyloxy group which may be substituted with one or more W2;
- W2 is a linear or branched C1-C6 alkyl group, a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 haloalkyl group, a halogen atom, a cyano group, or a nitro group;
- W3 is a linear or branched C1-C6 alkyl group, a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 alkylamino group, or a linear or branched C1-C6 dialkylamino group;
- Rc is a linear or branched C1-C6 alkyl group;
- and
- R1 and R2, which may be the same or different, each represent a hydrogen atom or a linear or branched C1-C6 alkyl group.
A compound represented by formula (III):
- wherein n is an integer selected from 1 to 20;
- Ra and Rb, which may be the same or different, are each selected from the group consisting of a linear or branched C1-C6 alkyl group substituted with one or more W1, a linear or branched C1-C6 alkylcarbonyl group which may be substituted with one or more W1, an arylcarbonyl group which may be substituted with one or more W2, a linear or branched C1-C6 alkoxycarbonyl group which may be substituted with one or more W1, an aryloxycarbonyl group which may be substituted with one or more W2, a linear or branched C1-C6 alkylaminocarbonyl group which may be substituted with one or more W1, a linear or branched C1-C6 dialkylaminocarbonyl group which may be substituted with one or more W1, a linear or branched C1-C6 alkylsulfonyl group which may be substituted with one or more W1, an arylsulfonyl group which may be substituted with one or more W2, and R1 and R2;
- or
- Ra and Rb may be joined together to form a group ═CH—W3;
- W1 is a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 alkylthio group, a linear or branched C1-C6 alkylsulfinyl group, a linear or branched C1-C6 alkylsulfonyl group, an aryl group which may be substituted with one or more W2, an aryloxy group which may be substituted with one or more W2, or a C1-C3 aralkyloxy group which may be substituted with one or more W2;
- W2 is a linear or branched C1-C6 alkyl group, a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 haloalkyl group, a halogen atom, a cyano group, or a nitro group;
- and
- W3 is a linear or branched C1-C6 alkyl group, a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 alkylamino group, or a linear or branched C1-C6 dialkylamino group.
Dependencies are inferred from the claim text.