Imidazo(2,1-b)-1,3,4-thiadiazole sulfoxides and sulfones

A compound represented by Formula I:

• or a pharmaceutically acceptable salt thereof wherein:
• n is 1 or 2;
• R is selected from the group consisting of:
• i. substituted or unsubstituted C (1-8) alkyl, fluoroalkyl, substituted and unsubstituted aralkyl, substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl;
• and
• wherein m is an integer between 1 and 5;
• and
• R3 and R4 are independently selected from the groups consisting of hydrogen, substituted or unsubstituted C (1-8) alkyl, fluoroalkyl, substituted and unsubstituted aralkyl, substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl, substituted or unsubstituted C (1-8) alkylcarbonyl, substituted or unsubstituted C (1-8) alkylaminocarbonyl, substituted or unsubstituted arylaminocarbonyl, substituted or unsubstituted heteroarylaminocarbonyl, substituted or unsubstituted C (1-8) alkylsulfonyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted heteroarylsulfonyl, or R3 and R4 are joined to form a substituted or unsubstituted cycloalkyl or cycloheteroalkyl ring system;
• and
• R5 and R6 are independently chosen from hydrogen, substituted or unsubstituted C (1-8) alkyl, or R5 and R6 are joined to form a cycloalkyl or cycloheteroalkyl ring system;
• R1 and R2 are independently selected from the group consisting of:
• (i) H, fluoro C(1-6)-alkyl, substituted and unsubstituted C(6-16)-aryl, substituted and unsubstituted heteroaryl, substituted and unsubstituted coumarinyl, and adamantyl;
• wherein
• X is represented by a bond, O or S(O)n, wherein n=0, 1, or 2, and is attached to ring A at the 2, 3, or 4 position;
• R23 on ring A is selected from the group consisting of H, halogen, C(1-8)alkyl, C(1-8) alkoxy and represents up to 4 substitutions;
• R24 through R28 of ring B is independently selected from the group consisting of:
• H, halogen, C(1-8) alkyl, C(1-8) fluoroalkyl, C(1-8) alkoxy,
• wherein any two adjacent R24 through R28 groups may be combined to form a fused aryl, substituted aryl, heteroaryl, or substituted heteroaryl ring system;
• and
• wherein
• X is represented by a bond, O or S(O)n, wherein n=0, 1, or 2;
• R23 on ring A is selected from the group consisting of:
• H, halogen, C(1-8) alkyl, C(1-8) alkoxy and represents up to 4 substitutions;
• R24 through R28 of ring B are independently selected from the group consisting of:
• H, halogen, C(1-8) alkyl, C(1-8) fluoroalkyl, and C(1-8) alkoxy;
• and wherein any two adjacent R24 through R28 groups may be combined to form a fused aryl, substituted aryl, heteroaryl, or substituted heteroaryl ring system;
• and
• wherein the heteroaryl ring systems of ring A and B contain at least one heteroatom and are substituted or unsubstituted.