Cyclic sulfamides for inhibiton of gamma-secretase

A compound of formula I:

• wherein the pyrazole group is attached at one of the positions indicated by an asterisk and X is attached at a position adjacent thereto;
• X represents H, OH, C1-4alkoxy, Cl or F;
• Ar represents phenyl or 6-membered heteroaryl, either of which bears 0-3 substituents independently selected from halogen, CF3, CHF2, CH2F, NO2, CN, OCF3, C1-6alkyl and C1-6alkoxy;
• R1 represents a hydrocarbon group of 1-5 carbon atoms which is optionally substituted with up to 3 halogen atoms;
• and
• R2 represents H or a hydrocarbon group of 1-10 carbon atoms which is optionally substituted with up to 7 halogen atoms;
• provided that when X is H, R2 does not represent 2,2,2-trifluoroethyl;
• or a pharmaceutically acceptable salt thereof.