Aroyl-piperidine derivatives
AssigneeNovartis AG
InventorSiem Veenstra
Life of this patent
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Abstract
The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidines of the formula . . . wherein Y and R each are as defined above and the ring A is unsubstituted or mono- or polysubstituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl; and the salts thereof, to the use thereof, to processes for the preparation thereof and to pharmaceutical compositions comprising a compound according to the invention.
Claims8
A compound of the formula
- wherein Y is ═N— or ═N(O)—, R is OH when Y is ═N— and R is H when Y is ═N(O)— and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, provided that when R is OH and Y is ═N— the ring A is not unsubstituted, and pharmaceutically acceptable salts thereof.
The compounds (2R,4S)-[1-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-piperidin-4-yl]-quinoline-N-oxide-4-carboxamide or a pharmaceutically acceptable salt thereof, or (2R,4S)-N-[1-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-piperidin-4-yl]-3-hydroxy-quinoline-4-carboxamide or a pharmaceutically acceptable salt thereof.
A method of treating disorders induced bv substance P comprising administering a therapeutically effective amount of a compound of formula I to an animal in need thereof.
(canceled)
Dependencies are inferred from the claim text.