Thieno-pyridine derivatives as allosteric enhancers of the GABAB receptors

A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I

• wherein
• R1 is hydrogen, C1-C7-alkyl, C1-C7-haloalkyl, or C3-C8-cycloalkyl;
• R2 is C1-C7-alkyl, C1-C7-haloalkyl, C3-C8-cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl having 5 to 9 ring atoms, wherein the substituents are selected from the group consisting of halo, C1-C7-alkoxy, C1-C7-haloalkyl, C1-C7-haloalkoxy, C1-C7-alkylsulfonyl, and —C(O)O—C1-C7-alkyl;
• R3 is —NRaRb;
• optionally substituted heterocycloalkyl having 3 to 8 ring atoms, optionally substituted aryl, or optionally substituted heteroaryl having 5 to 9 ring atoms, wherein the substituents are selected from the group consisting of halo, C1-C7-alkoxy, C1-C7-haloalkyl, C1-C7-haloalkoxy, C1-C7-alkylsulfonyl, and —C(O)O—C1-C7-alkyl;
• R4 is hydrogen, or C1-C7-alkyl;
• and R5 is hydrogen, halo, C1-C7-alkyl, —NRaRb, optionally substituted aryl or optionally substituted heteroaryl having 5 to 9 ring atoms, wherein the substituents are selected from the group consisting of halo, cyano, C1-C7-alkyl, C1-C7-haloalkyl, C1-C7-alkoxy, C1-C7-haloalkoxy, C1-C7-alkylsulfonyl, and —C(O)O—C1-C7-alkyl;
• or R5 together with R4 forms a ring selected from the group consisting of C5-C7-cycloalkyl, heterocycloalkyl having 5 to 7 ring atoms, phenyl, pyridinyl, and pyrimidinyl which are optionally substituted or by one or more halo, cyano, C1-C7-alkylsulfonyl, C1-C7-alkyl, C1-C7-haloalkyl, C1-C7-alkoxy, C1-C7-haloalkoxy, or —C(O)O—C1-C7-alkyl;
• Ra and Rb are each independently C1-C7-alkyl, or Ra and Rb, together with the nitrogen atom to which they are attached, form a heterocycloalkyl group having 3 to 8 ring atoms which is optionally substituted by one or more halo, C1-C7-alkyl, C1-C7-alkoxy, hydroxy, phenyl or di(C1-C7)alkylamino;
• or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.