Rapamycin derivatives and the uses thereof in the treatment of neurological disorders

A compound of the formula I:

• wherein:
• R1 and R2 are the same or different and are selected from the group consisting of CR16R17 and CR18R19;
• R3 and R4 are:
• (a) independently selected from the group consisting of H, OH, O(C1 to C6 alkyl), O(substituted C1 to C6 alkyl), O(acyl), O(aryl), O(substituted aryl), and halogen;
• or
• (b) taken together to form a double bond to O;
• R5, R6, and R7 are independently selected from the group consisting of H, OH, and OCH3;
• R8 and R9 are connected through a (i) single bond and are CH2 or (ii) double bond and are CH;
• R15 is selected from the group consisting of C═O, CHOH, and CH2;
• R16 and R17 are independently selected from the group consisting of H, C1 to C6 alkyl, C1 to C6 substituted alkyl, aryl, substituted aryl, acyl, CF3, CN, and NO2;
• R18 and R19 are independently selected from the group consisting of H, C1 to C6 alkyl, C1 to C6 substituted alkyl, aryl, substituted aryl, acyl, CF3, CN, and NO2;
• or
• R17 and R18 are taken together to form a carbon-based or heterocyclic 5- to 7-membered ring;
• n is 1 or 2;
• or a pharmaceutically acceptable salt thereof.