Benzo[b]pyrano[3,2-h]acridin-7-one cinnamate compounds

1- A compound selected from those of formula (I):

• wherein:
• X and Y, which may be the same or different, each independently represents a group selected from:
• hydrogen, halogen, hydroxy, linear or branched (C1-C6)alkoxy, nitro, cyano, linear or branched (C1-C6)alkyl (optionally substituted by one or more groups selected from hydroxy and halogen), linear or branched (C2-C6)alkenyl, and —NRaRb wherein:
• Ra and Rb, which may be the same or different, each independently represents a group selected from hydrogen and linear or branched (C1-C6)alkyl group, or
• Ra and Rb, together with the nitrogen atom carrying them, form a monocyclic, 5- to 7-membered heterocycle optionally having in the cyclic system a second heteroatom selected from oxygen and nitrogen,
• it being understood that the substituents X and Y may be present, independently of one another, on either of the two adjacent benzene rings,
• Z represents oxygen, and NRc wherein Rc represents a group selected from hydrogen, linear or branched (C1-C6)alkyl, aryl and aryl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched,
• Ar represents aryl or heteroaryl,
• R1 represents hydrogen or linear or branched (C1-C6)alkyl,
• R2 represents a group selected from hydrogen, linear or branched (C1-C6)alkyl, —ORa, and —NRaRb,
• R3 and R4, which may be the same or different, each independently represents hydrogen or linear or branched (C1-C6)alkyl,
• R5 represents a group selected from
• hydrogen,
• ORc and NRcRd wherein:
• Rd is as defined for Rc,
• W1—C(W2)—U—V wherein:
• W represents oxygen or NRc,
• W2 represents oxygen,
• U represents single bond or linear or branched (C1-C8)alkylene or linear or branched (C2-C8)alkenylene,
• V represents a group selected from:
• hydrogen,
• aryl or heteroaryl,
• OR, CO2Rc, CORc, CON′aR′b, NR′aR′b, N(Rc)—CO2R′c, N(Rc)—COR′c wherein R′c is as defined for Rc, and R′a and R′b, which may be the same or different, each independently represents a group selected from hydrogen, linear or branched (C1-C6)alkyl, aryl and aryl-(C1-C6)alkyl in which the alkyl moiety may be linear or branched or
• R′a and R′b, together with the nitrogen atom carrying them, form a monocyclic, 5- to 7-membered heterocycle optionally having in the cyclic system a second heteroatom selected from oxygen and nitrogen,
• W—C(W2)—W3—Ti wherein:
• W3 represents oxygen or NRc,
• T1 represents a group selected from
• hydrogen,
• linear or branched (C1-C6)alkyl,
• linear or branched (C2-C6)alkenyl,
• aryl,
• aryl-(C1-C6)alkyl in which the alkyl moiety may be linear or branched, and
• linear or branched (C1-C6)alkylene or linear or branched (C2-C6)alkenylene,
• each of which being substituted by a group selected from ORc and NR′aR′b, -Z-CO—CH═CHAr,
• its enantiomers and diastereoisomers, and addition salts, hydrates and solvates thereof with a pharmaceutically acceptable acid or base,
• it being understood that:
• “aryl” represents “phenyl” or “naphthyl” each of those groups being optionally substituted by one or more, identical or different, substituents selected from linear or branched (C1-C6)alkyl (optionally substituted by one or more hydroxy or halogen groups), hydroxy, halogen, carboxy, nitro, amino, linear or branched mono(C1-C6)alkylamino, di(C1-C6)alkylamino wherein each alkyl moiety may be linear or branched, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)acyl and linear or branched (C1-C6)alkylcarbonyloxy,
• “heteroaryl” represents a 5- to 12-membered group which either is monocyclic and aromatic or is bicyclic with at least one of the rings being of aromatic character, and which has one, two or three heteroatoms selected from oxygen, nitrogen and sulphur, it being understood that the heteroaryl group may be optionally substituted by one or more, identical or different, groups selected from halogen, linear or branched (C1-C6)alkyl optionally substituted by one or more hydroxyl groups or halogen atoms, hydroxy, linear or branched (C1-C6)alkoxy, and amino optionally substituted by one or two linear or branched (C1-C6)alkyl groups.