Novel synthesis of irbesartan
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsGennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky
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Abstract
Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
Claims12
A process of making 2-butyl-3-[2′-(1-triphenylmethyl-1H-tetrazol-5-yl)-biphenyl-4-yl methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, comprising the step of reacting 2-butyl-3-(4-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one with 2-((1-trityl-1H-tetrazol-5-yl))phenylboronic acid in a solvent system comprising first and second solvents in the presence of a catalyst.
Dependencies are inferred from the claim text.