PPAR active compounds

A compound having the chemical structure

• all salts, prodrugs, tautomers and stereoisomers thereof,
• wherein:
• U, V, W, X, and Y are independently N or CR5, wherein no more than two of U, V, W, and Y are N;
• R1 is selected from the group consisting of optionally substituted carboxyl and a carboxylic acid isostere;
• R2 is selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —OR10, —SR11, —NR12R13, —C(Z)NR6R7, —C(Z)R8, —S(O)2NR6R7, and —S(O)mR9;
• R3 and R4 are independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl, or R3 and R4 may combine to form a 3-7 membered optionally substituted mono-cycloalkyl or 3-7 membered optionally substituted mono-heterocycloalkyl;
• R5 at each occurrence is independently selected from the group consisting of hydrogen, halo, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —OR10, —SR11, —NR12R13, —C(Z)NR6R7, —C(Z)R8, —S(O)2NR6R7 and —S(O)mR9;
• R6 and R7 at each occurrence are independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R6 and/or R7 are optionally substituted lower alkenyl, no alkene carbon thereof is bound to nitrogen, optionally substituted lower alkynyl, provided, however, when R6 and/or R7 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to nitrogen, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl, or R6 and R7 together with the nitrogen to which they are attached form a 5-7 membered optionally substituted heterocycloalkyl or 5-7 membered optionally substituted heteroaryl;
• R8 at each occurrence is independently selected from the group consisting of optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R8 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to —C(Z)-, optionally substituted lower alkynyl, provided, however, that when R8 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to —C(Z)-, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, and —OR11;
• R9 at each occurrence is independently selected from the group consisting of optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R9 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to —S(O)m—, optionally substituted lower alkynyl, provided, however, that when R9 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to —S(O)m—, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl;
• R10 at each occurrence is independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R10 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to oxygen, optionally substituted lower alkynyl, provided, however, that when R10 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to oxygen, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —C(Z)R8, and —C(Z)NR6R7;
• R11 at each occurrence is independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R11 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to sulfur or oxygen, optionally substituted lower alkynyl, provided, however, that when R11 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to sulfur or oxygen, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl;
• R12 and R13 at each occurrence are independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R12 and/or R13 are optionally substituted lower alkenyl, no alkene carbon thereof is bound to nitrogen, optionally substituted lower alkynyl, provided, however, that when R12 and/or R13 are optionally substituted lower alkynyl, no alkyne carbon thereof is bound to nitrogen, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —C(Z)R8, —C(Z)NR6R7, —S(O)2R9, and —S(O)2NR6R7, or R12 and R13 together with the nitrogen to which they are attached form a 5-7 membered optionally substituted heterocycloalkyl or 5-7 membered optionally substituted heteroaryl;
• m is 1 or 2;
• Z is O or S;
• and
• n=0, 1, or 2.