Phosphodiesterase 4 inhibitors

A compound according to Formula I:

• wherein
• R1 is ethyl, isopropyl, cyclopropylmethyl, cyclobutylmethyl, or benzyl;
• R2 is alkyl having 1 to 4 carbon atoms, which is unsubstituted or substituted one or more times by halogen;
• R3 is —CH2CONR6R5, —CH2CONHR5, —CHR7CONR6R5 or —CHR7CONHR5;
• R5 is alkyl having 1 to 12 carbon atoms wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkyl having 1 to 12 carbon atoms which is substituted one or more times by halogen, oxo, or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkoxyalkyl having 3 to 8 carbon atoms which is unsubstituted or substituted one or more times by halogen, oxo, or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• cycloalkyl having 3 to 8 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl, or combinations thereof,
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl or combinations thereof,
• aryl having 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulphonamido, arylsulphonamido, halogenated arylsulphonamido, phenoxy, acylamido, and acyloxy, or combinations thereof,
• arylalkyl having 8 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, aminosulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof,
• a heterocyclic group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by halogen, alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, alkoxyalkyl, cyano, halogenated alkyl, halogenated alkoxy, nitro, oxo, amino, alkylamino, dialkylamino, carboxamide, aminosulphonyl, aryl which is optionally substituted by alkyl or alkoxy, arylalkyl which is optionally substituted by alkyl or alkoxy, aryloxyalkyl wherein the aryl portion is optionally substituted by alkyl or alkoxy, arylsulfonyl, anilino, heterocycle, heterocyclic-alkyl wherein the alkyl portion is optionally substituted by oxo, or combinations thereof, or
• a heterocyclic-alkyl group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times in the heterocyclic portion by halogen, aryl, alkyl, alkoxy, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, carboxy or combinations thereof and/or substituted in the alkyl portion by halogen, oxo, cyano, or combinations thereof;
• R6 is H,
• alkyl having 1 to 12 carbon atoms wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkyl having 1 to 12 carbon atoms which is substituted one or more times by halogen, oxo, or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkoxyalkyl having 3 to 8 carbon atoms which is unsubstituted or substituted one or more times by halogen, oxo, or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• cycloalkyl having 3 to 8 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl, or combinations thereof,
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl or combinations thereof,
• aryl having 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof,
• arylalkyl having 8 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof;
• a heterocyclic group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by halogen, aryl, alkyl, alkoxy, alkoxycarbonyl, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, or combinations thereof, or
• a heterocyclic-alkyl group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times in the heterocyclic portion by halogen, aryl, alkyl, alkoxy, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, carboxy or combinations thereof and/or substituted in the alkyl portion by halogen, oxo, cyano, or combinations thereof;
• and
• R7 is alkyl having 1 to 8 carbon atoms wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkyl having 1 to 8 carbon atoms which is substituted one or more times by halogen, oxo or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• cycloalkyl having 3 to 8 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl having 1 to 4 carbon atoms or combinations thereof, or
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl or combinations thereof;
• and pharmaceutically acceptable salts or solvates thereof, or solvates of pharmaceutically acceptable salts thereof.

A compound according to Formula I:

• wherein
• R1 is alkyl having 1 to 8 carbon atoms wherein optionally one or more —CH2CH2— groups are replaced in each case by CH═CH— or —C≡C— groups,
• alkyl having 1 to 8 carbon atoms which is substituted one or more times by halogen, oxo or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• cycloalkyl having 3 to 8 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl having 1 to 4 carbon atoms or combinations thereof,
• a heterocyclic group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times by halogen, aryl, alkyl, alkoxy, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, or combinations thereof,
• aryl having 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof,
• arylalkyl having 7 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof,
• a partially unsaturated carbocyclic group having 5 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl, alkoxy, nitro, cyano, oxo, or combinations thereof,
• arylalkenyl having 8 to 16 carbon atoms, wherein the alkenyl portion has up to 5 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof;
• a heterocyclic-alkyl group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times in the heterocyclic portion by halogen, aryl, alkyl, alkoxy, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, carboxy or combinations thereof and/or substituted in the alkyl portion by halogen, oxo, cyano, or combinations thereof, or
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl or combinations thereof,
• R2 is alkyl having 1 to 4 carbon atoms, which is unsubstituted or substituted one or more times by halogen;
• R3 is —CH2CONR6R5, —CH2CONHR5, —CHR7CONR6R5 or —CHR7CONHR5;
• R5 is isoxazolyl, pyrazolyl, or pyrazinyl, which in each case is unsubstituted or substituted one or more times by halogen, alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, alkoxyalkyl, cyano, halogenated alkyl, halogenated alkoxy, nitro, oxo, amino, alkylamino, dialkylamino, carboxamide, aminosulphonyl, aryl which is optionally substituted by alkyl or alkoxy, arylalkyl which is optionally substituted by alkyl or alkoxy, aryloxyalkyl wherein the aryl portion is optionally substituted by alkyl or alkoxy, arylsulfonyl, anilino, heterocycle, heterocyclic-alkyl wherein the alkyl portion is optionally substituted by oxo, or combinations thereof;
• R6 is H,
• alkyl having 1 to 12 carbon atoms wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkyl having 1 to 12 carbon atoms which is substituted one or more times by halogen, oxo, or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkoxyalkyl having 3 to 8 carbon atoms which is unsubstituted or substituted one or more times by halogen, oxo, or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• cycloalkyl having 3 to 8 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl, or combinations thereof,
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl or combinations thereof,
• aryl having 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof,
• arylalkyl having 8 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof;
• a heterocyclic group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by halogen, aryl, alkyl, alkoxy, alkoxycarbonyl, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, or combinations thereof, or a heterocyclic-alkyl group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times in the heterocyclic portion by halogen, aryl, alkyl, alkoxy, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, carboxy or combinations thereof and/or substituted in the alkyl portion by halogen, oxo, cyano, or combinations thereof;
• and
• R7 is alkyl having 1 to 8 carbon atoms wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkyl having 1 to 8 carbon atoms which is substituted one or more times by halogen, oxo or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• cycloalkyl having 3 to 8 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl having 1 to 4 carbon atoms or combinations thereof, or
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl or combinations thereof;
• and pharmaceutically acceptable salts or solvates thereof, or solvates of pharmaceutically acceptable salts thereof.

A compound according to Formula I:

• wherein
• R1 is alkyl having 1 to 8 carbon atoms wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkyl having 1 to 8 carbon atoms which is substituted one or more times by halogen, oxo or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• cycloalkyl having 3 to 8 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl having 1 to 4 carbon atoms or combinations thereof,
• a heterocyclic group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times by halogen, aryl, alkyl, alkoxy, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, or combinations thereof,
• aryl having 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof,
• arylalkyl having 7 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof,
• a partially unsaturated carbocyclic group having 5 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl, alkoxy, nitro, cyano, oxo, or combinations thereof,
• arylalkenyl having 8 to 16 carbon atoms, wherein the alkenyl portion has up to 5 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof;
• a heterocyclic-alkyl group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times in the heterocyclic portion by halogen, aryl, alkyl, alkoxy, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, carboxy or combinations thereof and/or substituted in the alkyl portion by halogen, oxo, cyano, or combinations thereof, or cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl or combinations thereof,
• R2 is alkyl having 1 to 4 carbon atoms, which is unsubstituted or substituted one or more times by halogen;
• R3 is —CH2CONR6R5, —CH2CONHR5, —CHR7CONR6R5 or —CHR7CONHR5;
• R5 is 3-isopropyl-1,2,4-thiadiazol-5-yl, methylisothiazolyl, cyclopropylthiazolyl, 5-cyclopropyl-1,3,4-thiadiazolyl, methylbenzothiazolyl, or methylisoxazolyl;
• R6 is H,
• alkyl having 1 to 12 carbon atoms wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkyl having 1 to 12 carbon atoms which is substituted one or more times by halogen, oxo, or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkoxyalkyl having 3 to 8 carbon atoms which is unsubstituted or substituted one or more times by halogen, oxo, or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• cycloalkyl having 3 to 8 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl, or combinations thereof,
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl or combinations thereof,
• aryl having 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof,
• arylalkyl having 8 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, acylamido, and acyloxy, or combinations thereof;
• a heterocyclic group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by halogen, aryl, alkyl, alkoxy, alkoxycarbonyl, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, or combinations thereof, or
• a heterocyclic-alkyl group, which is saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times in the heterocyclic portion by halogen, aryl, alkyl, alkoxy, cyano, halogenated alkyl, nitro, oxo, amino, alkylamino, dialkylamino, carboxy or combinations thereof and/or substituted in the alkyl portion by halogen, oxo, cyano, or combinations thereof;
• and
• R7 is alkyl having 1 to 8 carbon atoms wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• alkyl having 1 to 8 carbon atoms which is substituted one or more times by halogen, oxo or combinations thereof wherein optionally one or more —CH2CH2— groups are replaced in each case by —CH═CH— or —C≡C— groups,
• cycloalkyl having 3 to 8 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl having 1 to 4 carbon atoms or combinations thereof, or
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, oxo, alkyl or combinations thereof;
• and pharmaceutically acceptable salts or solvates thereof, or solvates of pharmaceutically acceptable salts thereof.

A compound selected from:

• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-1,3,4-thiadiazol-2-ylacetamide,
• N-[5-(2-furyl)-1,3,4-thiadiazol-2-yl]-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-[5-(2-piperidin-1-ylethyl)-1,3,4-thiadiazol-2-yl]acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(3-phenyl-1,2,4-thiadiazol-5-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)acetamide,
• N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• 2-((S)-4-{4-Methoxy-3-[(R)-(tetrahydrofuran-3-yl)oxy]-phenyl}-2-oxo-pyrrolidin-1-yl)-N-(5-(1-tert-butyloxycarbonylpiperidin)-4-yl-[1,3,4]thiadiazol-2-yl)-acetamide;
• 2-((S)-4-{4-Methoxy-3-[(R)-(tetrahydrofuran-3-yl)oxy]-phenyl}-2-oxo-pyrrolidin-1-yl)-N-(3-methyl-isothiazol-5-yl)-acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(5-methylisoxazol-3-yl)acetamide,
• N-Isoxazol-3-yl-2-((S)-4-{4-methoxy-3-[(R)-(tetrahydrofuran-3-yl)oxy]-phenyl}-2-oxo-pyrrolidin-1-yl)-acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(3-methyl-1H-pyrazol-5-yl)acetamide,
• N-(4-Benzenesulfonyl-thiophen-3-yl)-2-((S)-4-{4-methoxy-3-[(R)-(tetrahydrofuran-3-yl)oxy]-phenyl}-2-oxo-pyrrolidin-1-yl)-acetamide,
• 2-((S)-4-{4-Methoxy-3-[(R)-(tetrahydrofuran-3-yl)oxy]-phenyl}-2-oxo-pyrrolidin-1-yl)-N-(1H-pyrazol-3-yl)-acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(3-methyl-1,2,4-thiadiazol-5-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)acetamide,
• N-(3-ethyl-1,2,4-thiadiazol-5-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• 5-{[((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetyl]amino}-3-methylisoxazole-4-carboxamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(3-methylisoxazol-5-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(5-methyl-3-phenylisoxazol-4-yl)acetamide,
• N-(3,5-dimethylisoxazol-4-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-pyrazin-2-ylacetamide,
• N-(2-Ethyl-2H-pyrazol-3-yl)-2-((S)-4-{4-methoxy-3-[(R)-(tetrahydrofuran-3-yl)oxy]-phenyl}-2-oxo-pyrrolidin-1-yl)-acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(3-phenylisoxazol-5-yl)acetamide,
• N-(3-anilino-1,2,4-thiadiazol-5-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• 2-{(4R)-4-[3-(benzyloxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-methylisothiazol-5-yl)acetamide,
• 2-{(4S)-4-[3-(benzyloxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-methylisothiazol-5-yl)acetamide,
• N-(3-cyano-2-thienyl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-[4-(2-thienyl)-1,3-thiazol-2-yl]acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-[4-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide,
• 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-fluorophenyl)acetamide,
• 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-methyl-1H-pyrazol-5-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-methyl-N-(3-methylisothiazol-5-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-methyl-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(5-methylisoxazol-3-yl)acetamide,
• 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-methylisothiazol-5-yl)acetamide,
• 2-[4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(6-methylpyridin-2-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide,
• (4S)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]pyrrolidin-2-one,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(5-methyl-1H-pyrazol-3-yl)acetamide,
• (4R)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]pyrrolidin-2-one,
• (4S)-4-{4-(difluoromethoxy)-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}pyrrolidin-2-one,
• (4R)-4-{4-(difluoromethoxy)-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}pyrrolidin-2-one,
• (4S)-4-[3-(cyclobutylmethoxy)-4-(difluoromethoxy)phenyl]pyrrolidin-2-one,
• (4R)-4-[3-(cyclobutylmethoxy)-4-(difluoromethoxy)phenyl]pyrrolidin-2-one,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(6-methylpyridin-2-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-methylisoxazol-5-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-methylisothiazol-5-yl)acetamide,
• 2-((4S)-4-{4-Methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-methyl-N-phenylacetamide,
• 2-{4-[3-(cyclobutylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide,
• 2-{4-[3-(cyclobutylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(5-methylisoxazol-3-yl)acetamide,
• 2-{4-[3-(cyclobutylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(6-methylpyridin-2-yl)acetamide,
• 2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-methyl-N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)acetamide,
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-methylacetamide,
• 2-{4-[3-(cyclobutylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)-N-methylacetamide,
• N-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-2-((4S)-4-{4-methoxy-3-[(3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-methylacetamide,
• 2-{(4S)-4-[3-(cyclobutylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(5-methylisoxazol-3-yl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide,
• 2-{(4R)-4-[3-(cyclobutylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(5-methylisoxazol-3-yl)acetamide,
• 2-{(4R)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide,
• N-ethyl-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• N-(cyclopropylmethyl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• N-(cyclopropylmethyl)-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• 2-{(4R)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-{(4R)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-methylisothiazol-5-yl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-methylisothiazol-5-yl)acetamide,
• 2-{(4S)-4-[3-(cyclobutylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide,
• N-(cyclopropylmethyl)-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-N-methylacetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(cyclopropylmethyl)-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(cyclopropylmethyl)-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methyl-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-methyl-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-{4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-N-methylacetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-fluorophenyl)acetamide,
• 2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-fluorophenyl)acetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methyl-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide,
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide,
• N-(cyclopropylmethyl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide,
• 2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide,
• N-(cyclopropylmethyl)-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• N-(cyclopropylmethyl)-2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide,
• N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-((4S)-4-{4-methoxy-3-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-2-oxopyrrolidin-1-yl)acetamide,
• 2-{(4R)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-N-methylacetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-N-methylacetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-methylisothiazol-5-yl)acetamide,
• 2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-methylisothiazol-5-yl)acetamide,
• (4R)-4-[3-(benzyloxy)-4-(difluoromethoxy)phenyl]pyrrolidin-2-one,
• (4S)-4-[3-(benzyloxy)-4-(difluoromethoxy)phenyl]pyrrolidin-2-one,
• (4R)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]pyrrolidin-2-one,
• (2R)-2-{(4S)-4-[3-(benzyloxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-methylisothiazol-5-yl)propanamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide,
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide,
• N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)acetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-benzothiazol-2-yl)acetamide,
• 2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-N-methylacetamide,
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide,
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide,
• N-(3-fluorophenyl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-methyl-1H-pyrazol-5-yl)acetamide,
• 2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-fluorophenyl)-N-methylacetamide,
• 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide,
• 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide,
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}acetamide,
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methylacetamide,
• 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide,
• 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)-N-methylacetamide,
• N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)-N-methylacetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(4-cyclopropyl-1,3-thiazol-2-yl)acetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-[4-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methoxy-1,3-benzothiazol-2-yl)acetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methyl-N-(3-methylisothiazol-5-yl)acetamide,
• 2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(5-methylisoxazol-3-yl)acetamide,
• (2S)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide,
• (2R)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide,
• (2S)-2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide,
• (2R)-2-[(4R)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)propanamide,
• (2R)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)propanamide,
• (2S)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)propanamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(6-methylpyridin-2-yl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-1,3-thiazol-2-ylacetamide,
• N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide,
• N-(3-fluorophenyl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(5-methylisoxazol-3-yl)acetamide,
• N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[(4S)-4-(3-isopropoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide,
• N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[(4S)-4-(3-ethoxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-N-methylacetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(4-cyclopropyl-1I 3-thiazol-2-yl)-N-methylacetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methyl-N-(5-methylisoxazol-3-yl)acetamide,
• 2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide,
• 2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide,
• 2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide,
• N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}acetamide,
• N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methylacetamide,
• 2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)-N-methylacetamide,
• N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methylacetamide,
• (4R)-4-[4-(difluoromethoxy)-3-methoxyphenyl]pyrrolidin-2-one,
• (4R)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]pyrrolidin-2-one,
• (4R)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-1-isopropylpyrrolidin-2-one,
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}acetamide,
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-methylacetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)-N-methylacetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)-N-methylacetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(4-cyclopropyl-1,3-thiazol-2-yl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)acetamide,
• 2-{(4S)-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-(4-cyclopropyl-1,3-thiazol-2-yl)-N-methylacetamide, and
• 2-{(4S)-4-[4-(difluoromethoxy)-3-ethoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-methylisothiazol-5-yl)acetamide
• and pharmaceutically acceptable salts thereof, solvates thereof, and solvates of pharmaceutically acceptable salts thereof,
• wherein if the compound exhibits chirality it can be in the form of a mixture of enantiomers such as a racemate or a mixture of diastereomers, or can be in the form of a single enantiomer or a single diastereomer.