Fused heterocyclic compounds
AssigneeTakeda Pharmaceutical Company Limited
InventorsSatoru Oi, Hironobu Maezaki, Koji Ikedou
Life of this patent
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Abstract
A compound represented by the formula wherein ring A is an optionally substituted 5- to 10-membered aromatic ring; R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X and Y are the same or different and each is a bound, —O—, —S—, —SO—, —SO?2#191- or —NR3— (R3 is a hydrogen atom or an optionally substituted hydrocarbon group); and L is a divalent hydrocarbon group, or a salt thereof shows a superior peptidase-inhibitory activity and is useful as a prophylactic or therapeutic agent of diabetes and the like.
Claims24
A compound represented by the formula
- wherein
- ring A is an optionally substituted 5- to 10-membered aromatic ring;
- R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group;
- X and Y are the same or different and each is a bond, —O—, —S—, —SO—, —SO2— or —NR3— (R3 is a hydrogen atom or an optionally substituted hydrocarbon group);
- and
- L is a divalent hydrocarbon group,
- or a salt thereof.
22-26. (canceled)
A method of producing a compound represented by the formula
- wherein
- ring A is an optionally substituted 5- to 10-membered aromatic ring;
- R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group;
- X and Y are the same or different and each is a bond, —O—, —S—, —SO—, —SO2— or —NR3— (R3 is a hydrogen atom or an optionally substituted hydrocarbon group);
- La is a bond or a divalent hydrocarbon group,
- or a salt thereof, which comprises reacting a compound represented by the formula
- wherein L1 is a leaving group, and other symbols are as defined above, or a salt thereof with an aminating agent.
A method of producing a compound represented by the formula
- wherein
- ring A is an optionally substituted 5- to 10-membered aromatic ring;
- R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group;
- X and Y are the same or different and each is a bond, —O—, —S—, —SO—, —SO2— or —NR3— (R3 is a hydrogen atom or an optionally substituted hydrocarbon group);
- La is a bond or a divalent hydrocarbon group,
- or a salt thereof, which comprises subjecting a compound represented by the formula
- wherein the symbols in the formula are as defined above, or a salt thereof to reduction reaction.
Dependencies are inferred from the claim text.