Use of amprenavir as a radiation sensitizer
AssigneeThe Trustees of the University of Pennsylvania
InventorsAnjali Gupta, George Cerniglia
Life of this patent
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Abstract
The present invention relates to the sensitization of a cell to radiation. In particular, the present invention relates to the use of a protease inhibitor to sensitize a cancer cell to radiation.
Claims13
A method of sensitizing a cell to radiation, said method comprising contacting said cell with a composition comprising amprenavir.
A method of identifying a compound that sensitizes a cell to radiation, wherein said compound inhibits the phosphorylation of Akt, said method comprising contacting a cell with a test compound, wherein a lower level of sensitivity to radiation of said cell contacted with said test compound compared with the level of sensitivity to radiation of a second otherwise identical cell not contacted with said test compound is an indication that said test compound sensitizes a cell to radiation;
- thereby identifying a compound that sensitizes a cell to radiation.
A method of identifying a compound that sensitizes a cell to radiation, wherein said compound inhibits Akt, said method comprising contacting a cell with a test compound, wherein a lower level of sensitivity to radiation of said cell contacted with said test compound compared with the level of sensitivity to radiation of a second otherwise identical cell not contacted with said test compound is an indication that said test compound sensitizes a cell to radiation, thereby identifying a compound that sensitizes a cell to radiation.
A method of identifying a compound that sensitizes a cell to radiation, wherein said compound inhibits the phosphorylation of PI3K, said method comprising contacting a cell with a test compound, wherein a lower level of sensitivity to radiation of said cell contacted with said test compound compared with the level of sensitivity to radiation of a second otherwise identical cell not contacted with said test compound is an indication that said test compound sensitizes a cell to radiation, thereby identifying a compound that sensitizes a cell to radiation.
A method of reducing the growth of a tumor in a mammal, said method comprising:
- a.) contacting said tumor with a composition comprising amprenavir;
- and
- b.) irradiating said mammal;
- thereby reducing the growth of said tumor in said mammal.
A method of eliminating a tumor from a mammal, said method comprising:
- a.) contacting said tumor with a composition comprising amprenavir and
- b.) irradiating said mammal;
- thereby eliminating said tumor from said mammal.
Dependencies are inferred from the claim text.