Method of treating neurological diseases and disorders
AssigneeThe Trustees of the University of Pennsylvania
InventorsGideon Dreyfuss, Jin Wang
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Abstract
The present invention provides methods for treating neurological diseases and disorders. Compounds that replace or enhance the function of SMN or alleviate or reduce a phenotype of cells with low SMN protein levels are provided. Screening methods and kits for identifying such compounds also are provided.
Claims8
A method of treating a neurodegenerative disease or disorder comprising administering an effective amount of a compound that replaces or enhances the function of SMN to alleviate or reduce a phenotype of cells with low SMN protein levels.
A method of identifying a psychopharmacological agent comprising contacting a test cell, which has low SMN protein levels, with a test agent and detecting an ability of said agent to alleviate or reduce a phenotype of said cells, wherein the ability of said agent to alleviate or reduce a phenotype said cells is indicative of said agent being a psychopharmacological agent.
A method of treating a psychiatric disease or disorder comprising administering an effective amount of Compound 38, Compound 39, or Compound 40.
A kit for identifying a psychopharmacological agent comprising a test cell, which has low SMN protein levels, and a positive or negative standard.
Dependencies are inferred from the claim text.