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US 2006/0135501 A1Published application
Piperidinyl-thiazole carboxylic acid derivatives as angiogenesis inhibitors
OwnerPeter Knox, Michele O'Sullivan +1inventors
InventorsPeter Knox, Michele O'Sullivan, Heike Lentfer
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Abstract
This invention relates to compounds of formula (I) and (II) that are useful in treating vascular endothelial growth factor (VEGF)-mediated disorders, particularly endometriosis and acute macular degenerative disorder. The invention also relates to a topical system for the treatment of acute macular degenerative disorder comprising a VEGF inhibitor.
Claims46
A compound of formula (I) or formula (II):
- wherein:
- Q is an optionally substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, alkylthio, aralkylthio, amino, alkylamino, dialkylamino, carboxyl, carboxylalkyl, esterified carboxyl, alkylsulfoxyl, alkylsulfonyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy, or heterocyclic group;
- A is a single bond or alkylene;
- X is O or S;
- Z is O, S or NR3;
- p is 0 or 1;
- q is 0 or 1;
- n is an integer from 0 to 10;
- m is an integer from 0 to 10;
- W is an optionally substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, alkylthio, aralkylthio, amino, alkylamino, dialkylamino, carboxyl, carboxylalkyl, esterified carboxyl, alkylsulfoxyl, alkylsulfonyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy, or heterocyclic group;
- R1 is H or alkyl;
- R2 is independently H or alkyl;
- and
- R3 is H or alkyl;
- or a pharmaceutically acceptable derivative thereof.
12 more elements
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Dependencies are inferred from the claim text.