Compositions useful for the treatment of microbial infections
AssigneeThe Regents of the University of California
InventorsWenyuan Shi, Li Chen, Qing-yi Lu, David Heber, Maxwell Anderson
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Abstract
The present invention is based on the discovery that certain chemical compounds isolated from Chinese medicinal herbs are useful as anti-microbial agents, e.g., anti-bacterial agents, anti-fungal agents, and the like. In particular, the present invention provides compositions useful for treating microbial infections such as, for example, oral microbial infections, including periodontal disease and dental caries.
Claims44
A composition comprising at least two compounds selected from the group consisting of kurarinone, berberine, dioscin, perillaldehyde, α-linolenic acid, and polyphyllin D.
A composition comprising perillaldehyde and at least one compound selected from the group consisting of kurarinone, berberine, dioscin, α-linolenic acid, and polyphyllin D.
A composition comprising polyphyllin D and at least one compound selected from the group consisting of kurarinone, berberine, α-linolenic acid, and perillaldehyde.
A composition comprising dioscin and at least one compound selected from the group consisting of kurarinone, berberine, α-linolenic acid, and perillaldehyde.
A composition comprising kurarinone, berberine, dioscin, and α-linolenic acid.
A composition comprising kurarinone, berberine, α-linolenic acid, and polyphyllin D.
A pharmaceutical composition comprising an active component and a pharmaceutically acceptable carrier, wherein the active component consists at least one compound selected from the group consisting of kurarinone, berberine, dioscin, perillaldehyde, α-linolenic acid, and polyphyllin D.
A pharmaceutical composition comprising an active component and a pharmaceutically acceptable carrier, wherein the active component comprises perillaldehyde and at least one compound selected from the group consisting of kurarinone, berberine, dioscin, perillaldehyde, α-linolenic acid, and polyphyllin D.
A method of inhibiting the activity of a microorganism comprising contacting the microorganism with a composition of at least one compound selected from the group consisting of kurarinone, berberine, dioscin, perillaldehyde, α-linolenic acid, and polyphyllin D.
A method of treating or preventing a microbial infection comprising administering to a subject in need of such treatment a composition comprising at least one compound selected from the group consisting of kurarinone, berberine, dioscin, perillaldehyde, α-linolenic acid, and polyphyllin D.
A method of preventing a microbial infection comprising contacting a composition to an area susceptible to a microorganism causing the microbial infection, wherein the composition comprises at least one compound selected from the group consisting of kurarinone, berberine, dioscin, perillaldehyde, α-linolenic acid, and polyphyllin D.
Dependencies are inferred from the claim text.