Anti-HIV agents with dual sites of action

A compound according to Formula I::

• wherein:
• a is 1 or 2;
• R10 and R11 are each either H or loweralkyl;
• R12 is H, loweralkyl, or —CR2R3R4;
• R13 and R14 are each either H or form a bond with one another;
• R is a substituent of the formula:
• wherein:
• R′ and R″ are the same or different, are hydrogen atoms or alkyl radicals,
• X is a bond or represents a carbamoyl, N-methylcarbamoyl, aminocarbonyl or N-methylaminocarbonyl radical,
• Y is a bond or represents a phenylene radical,
• Ro and Roo are the same or different, and are hydrogen atoms or alkyl radicals, or Ro is hydroxyl, hydroxyalkyl, phenyl, benzyl, carbamoylmethyl or else, when Y is a bond and X is carbamoyl, Ro can form a 5- or 6-membered ring with the nitrogen atom contained in X, it being possible for this ring to additionally comprise another hetero atom chosen from oxygen or sulphur and,
• n, m and p are each integers from 0 to 16, and m+n+p is between 4 and 16;
• or
• R is a substituent of the formula
• where R″, Ro, Roo, X, Y, n, m and p are as given above and Z is an amino acid radical radical joined to the adjacent nitrogen atom by a peptide bond to the amino terminus of the amino acid radical;
• R1 is a C2 to C20 substituted or unsubstituted carboxyacyl;
• or
• R1 is a substituent of the formula
• where Ra and Rb are the same or different and are each either hydrogen or loweralkyl, and i is an integer of from 0 to 3;
• R2 is a methyl radical or forms with R4 a methylene radical or an oxo radical,
• R3 is a hydroxyl, methyl or hydroxymethyl radical or a radical —CH2OR′2, CH2SR′2 or —CH2NHR′2 for which R′2 is alkyl, hydroxyalkyl, dihydroxyalkyl, acetamidoalkyl or acetyl, or R2 is an amino radical substituted with a hydroxyalkyl or carboxyhydroxyalkyl radical, or a dialkylamino radical, the alkyl parts of which can form, with the nitrogen atom to which they are joined, a 5- or 6-membered heterocycle optionally containing another hetero atom chosen from oxygen, sulphur or nitrogen and, optionally, N-alkyl,
• R4 is a hydrogen atom or forms, with R2 or R3, a methylene radical or an oxo radical,
• R5 and R6 are each hydrogen or together form an oxo radical;
• or a pharmaceutically acceptable salt thereof.