Vitamin D3 analog useful for the treatment of osteoporosis
OwnerRoger Bouillon, Pierre De Clercq +3inventors
InventorsRoger Bouillon, Pierre De Clercq, Wim Schepens, Maurits Vandewalle, Annemieke Verstuyf
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Abstract
The present invention relates to the vitamin D3 analog (1R,3R)-5-{(E)-(2R, 5R)-2-[2-(4-hydroxy-4-methylpentyl)-spiro[4.5]dec-7-ylidene]-ethylidene}-cyclohexane-1,3-diol which is useful in the treatment of osteoporosis.
Claims17
The compound having the following structural formula:
- i.e. (1R,3R)-5-{(E)-(2R,5R)-2-[2-(4-hydroxy-4-methylpentyl)-spiro[4.5]dec-7-ylidene]-ethylidene}-cyclohexane-1,3-diol.
A composition comprising the compound having the formula
- i.e. (1R,3R)-5-{(E)-(2R,5R)-2-[2-(4-Hydroxy-4-methylpentyl)-spiro[4.5]dec-7-ylidene]-ethylidene}-cyclohexane-1,3-diol.
The composition of claim-2, comprising:
- a) (1R,3R)-5-{(E)-(2R,5R)-2-[2-(4-hydroxy-4-methylhexyl)-spiro[4.5]dec-7-ylidene]-ethylidene}-cyclohexane-1,3-diol in an amount effective for controlling osteoporosis;
- and
- b) one or more excipients.
A method of treating or preventing a bone disorder comprising administering to a human or a mammal an effective amount of a composition comprising the compound having the structural formula
- i.e. (1R,3R)-5-{(E)-(2R,5R)-2-[2-(4-hydroxy-4-methylpentyl)-spiro[4.5]dec-7-ylidene]-ethylidene}-cyclohexane-1,3-diol.
Dependencies are inferred from the claim text.