Vesicant treatment with phenyl-thiophene type vitamin d receptor modulators

A method of treating a mammal to prevent or alleviate the effect of Mustard by administering a pharmaceutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt or a prodrug derivative thereof:

• wherein;
• R and R′ are independently C1-C5 alkyl, C1-C5 fluoroalkyl, or together R and R′ form a substituted or unsubstituted, saturated or unsaturated carbocyclic ring having from 3 to 8 carbon atoms;
• Ring atoms Q1 and Q2 are independently selected from carbon or sulfur, with the proviso that one atom is sulfur and the other atom is carbon;
• RP and RT are independently selected from the group consisting of hydrogen, halo, C1-C5 alkyl, C1-C5 fluoroalkyl, —O—C1-C5 alkyl, —S—C1-C5 alkyl, —O—C1-C5 fluoroalkyl, —CN, —NO2, acetyl, —S—C1-C5 fluoroalkyl, C2-C5 alkenyl, C3-C5 cycloalkyl,
• and C3-C5 cycloalkenyl;
• (LP) and (LT) are divalent linking groups independently selected from the group consisting of
• where m is 0, 1 or 2, X1 is oxygen or sulfur, and each R40 is independently hydrogen or C1-C5 alkyl or C1-C5 fluoroalkyl;
• ZP and ZT are independently selected from
• -hydrogen,
• -phenyl,
• -benzyl,
• -fluorophenyl,
• —(C1-C5 alkyl),
• —(C2-C5 alkenyl),
• —(C3-C5 cycloalkyl),
• —(C3-C5 cycloalkenyl),
• —(C1-C5 hydroxyalkyl),
• —(C1-C5 fluoroalkyl),
• —(C1-C5 alkyl)-phenyl,
• —(C1-C5 alkyl)-O—(C1-C5) alkyl,
• —(C1-C5 alkyl)-NH2,
• —(C1-C5 alkyl)-NH—(C1-C5 alkyl),
• —(C1-C5 alkyl)-N—(C1-C5 alkyl)2,
• —(C1-C5 alkyl)-C(O)—NH2,
• —(C1-C5 alkyl)-C(O)—NH—(C1-C5 alkyl),
• —(C1-C5 alkyl)-C(O)—N—(C1-C5 alkyl)2,
• —(C1-C5 alkyl)-C(O)—(C1-C5 alkyl),
• —(C1-C5 alkyl)-NH—SO2—(C1-C5 alkyl),
• —(C1-C5 alkyl)-N-pyrrolidin-2-one,
• —(C1-C5 alkyl)-N-pyrrolidine,
• —(C1-C5 alkyl)-(1-methylpyrrolidin-2-one-3-yl),
• —(C1-C5 alkyl)-C(O)—(O—C1-C5 alkyl),
• —(C1-C5 alkyl)-C(O)—OH,
• —(C1-C5 alkyl)-5-tetrazolyl,
• —(C1-C5 alkyl)-P(O)—(O-C1-C5 alkyl)2,
• —(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —(C1-C5 alkyl)-SO2—NH2,
• —(C1-C5 alkyl)-SO2—NH—(C1-C5 alkyl),
• —(C1-C5 alkyl)-SO2—N—(C1-C5 alkyl)2,
• —(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —(C1-C5 alkyl)-S(O)—(C1-C5 alkyl),
• —(C1-C5 alkyl)-S(O)—NH2,
• —(C1-C5 alkyl)-S(O)—NH—(C1-C5 alkyl),
• —(C1-C5 alkyl)-S(O)—N—(C1-C5 alkyl)2,
• —(C1-C5 alkyl)-S(O)—(C1-C5 alkyl),
• —(C1-C5 alkyl)-N(C(O)(C1-C5 alkyl)CH2C(O)OH,
• —(C1-C5 alkyl)-N(C(O)(C1-C5 alkyl)CH2C(O)—(C1-C5 alkyl),
• —CH(OH)—(C1-C5 alkyl)
• —CH(OH)—(C2-C5 alkenyl),
• —CH(OH)—(C3-C5 cycloalkyl),
• —CH(OH)—(C3-C5 cycloalkenyl),
• —CH(OH)—(C1-C5 hydroxyalkyl),
• —CH(OH)—(C1-C5 fluoroalkyl),
• —CH(OH)-phenyl
• —CH(OH)-5-tetrazolyl,
• —CH(OH)-(1-methylpyrrolidin-2-one-3-yl),
• —C(O)—(C1-C5 alkyl),
• —C(O)—(C1-C5 alkyl)-C(O)OH,
• —C(O)—(C1-C5 alkyl)-C(O)(O—C1-C5 alkyl),
• —C(O)—(C2-C5 alkenyl),
• —C(O)—(C3-C5 cycloalkyl),
• —C(O)—(C3-C5 cycloalkenyl),
• —C(O)—(C1-C5 hydroxyalkyl),
• —C(O)—(C1-C5 fluoroalkyl),
• —C(O)—(C1-C5 alkyl)-phenyl
• —C(O)—O—(C1-C5 alkyl),
• —C(O)—O—(C2-C5 alkenyl),
• —C(O)—O—(C3-C5 cycloalkyl),
• —C(O)—O—(C3-C5 cycloalkenyl),
• —C(O)—O—(C1-C5 hydroxyalkyl),
• —C(O)—O—(C1-C5 fluoroalkyl),
• —C(O)—O—(C1-C5 alkyl)-phenyl,
• —C(O)—NH2,
• —C(O)—NH(OH),
• —C(O)—NH—(C1-C5 alkyl),
• —C(O)—N—(C1-C5 alkyl)2,
• —C(O)—NH—(C2-C5 alkenyl),
• —C(O)—NH—(C3-C5 cycloalkyl),
• —C(O)—NH—(C3-C5 cycloalkenyl),
• —C(O)—NH—(C1-C5 fluoroalkyl),
• —C(O)—NH—(C1-C5 alkyl)-phenyl,
• —C(O)—NH—SO2—(C1-C5 alkyl),
• —C(O)—NH—SO2—(C2-C5 alkenyl),
• —C(O)—NH—SO2—(C3-C5 cycloalkyl),
• —C(O)—NH—SO2—(C3-C5 cycloalkenyl),
• —C(O)—NH—S(O)—(C1-C5 alkyl),
• —C(O)—NH—S(O)—(C2-C5 alkenyl),
• —C(O)—NH—S(O)—(C3-C5 cycloalkyl),
• —C(O)—NH—S(O)—(C3-C5 cycloalkenyl),
• —C(O)—NH—(C1-C5 fluoroalkyl),
• —C(O)—NH—(C1-C5 alkyl)-phenyl
• —C(O)—NH—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —C(O)—NH—(C1-C5 alkyl)-S(O)—(C1-C5 alkyl),
• —C(O)—NH—CH2—C(O)OH
• —C(O)—NH—CH2—C(O)—(O—C1-C5 alkyl),
• —C(O)—N—(C1-C5 alkyl)(C(O)OH),
• —C(O)—N—(C1-C5 alkyl)(C(O)—(O—C1-C5 alkyl)),
• —C(O)—NH—CH((CH2)(CO2H))(CO2H),
• —C(O)—NH—CH((CH2)(C(O)—(C1-C5 alkyl)))(C(O)—(O—C1-C5 alkyl)),
• —C(O)—NH—CH((CH2OH)(CO2H)),
• —C(O)—NH—CH((CH2OH)(C(O)(O—C1-C5 alkyl)),
• —C(O)—NH—C((C1-C5 alkyl)(C1-C5 alkyl))(CO2H),
• —C(O)—NH—C((C1-C5 alkyl)(C1-C5 alkyl))(C(O)—(O—C1-C5 alkyl)),
• —C(O)—NH-5-tetrazolyl,
• —C(O)—N-pyrrolidin-2-one,
• —C(O)—N-pyrrolidine,
• —C(O)-(1-methylpyrrolidin-2-one-3-yl),
• —C(O)—(C1-C5 alkyl)-N-pyrrolidin-2-one,
• —C(O)—(C1-C5 alkyl)-N-pyrrolidine,
• —C(O)—(C1-C5 alkyl)-(1-methylpyrrolidin-2-one-3-yl),
• —C(O)—N-pyrrolidin-2-(CO2H),
• —C(O)—N-pyrrolidin-2-(C(O)—(O—C1-C5 alkyl)),
• —C(O)—N—(C(O)—(C1-C5 alkyl))CH2)(CO2H),
• —C(O)—N—(C(O)—(C1-C5 alkyl))CH2)(C(O)—(O—C1-C5 alkyl)),
• —C(O)—N—(C1-C5 alkyl))CH2(CO2H),
• —C(O)—C(O)—OH,
• —C(O)—C(O)—(C1-C5 alkyl),
• —C(O)—C(O)—(C2-C5 alkenyl),
• —C(O)—C(O)—(C3-C5 cycloalkyl),
• —C(O)—C(O)—(C3-C5 cycloalkenyl),
• —C(O)—C(O)—(C1-C5 hydroxyalkyl),
• —C(O)—C(O)—(C1-C5 fluoroalkyl),
• —C(O)—C(O)—(C1-C5 alkyl)-phenyl,
• —C(O)—C(O)—NH2,
• —C(O)—C(O)—NH—(C1-C5 alkyl),
• —C(O)—C(O)—N—(C1-C5 alkyl)2,
• —C(O)—C(O)-5-tetrazolyl,
• —C(O)—C(O)—N-pyrrolidin-2-one,
• —C(O)—C(O)—N-pyrrolidine,
• —C(O)—C(O)-(1-methylpyrrolidin-2-one-3-yl),
• —O—(C1-C5 alkyl),
• —O—(C2-C5 alkenyl),
• —O—(C3-C5 cycloalkyl),
• —O—(C3-C5 cycloalkenyl),
• —O—(C1-C5 hydroxyalkyl),
• —O—(C1-C5 fluoroalkyl),
• —O—(C1-C5 alkyl)-phenyl,
• —O—(C1-C5 alkyl)-(O)—(C1-C5 alkyl),
• —O—(C1-C5 alkyl) NH2,
• —O—(C1-C5 alkyl)-NH—(C1-C5 alkyl)2,
• —O—(C1-C5 alkyl)-C(O)—NH2,
• —O—(C1-C5 alkyl)-C(O)—NH—(C1-C5 alkyl),
• —O—(C1-C5 alkyl)-C(O)—N—(C1-C5 alkyl)2,
• —O—(C1-C5 alkyl)-C(O)—OH,
• —O—(C1-C5 alkyl)-C(O)—NH-5-tetrazolyl,
• —O—(C1-C5 alkyl)-C(O)—(C1-C5 alkyl),
• —O—(C1-C5 alkyl)-C(O)—(O—C1-C5 alkyl),
• —O—(C1-C5 alkyl)-NH2,
• —O—(C1-C5 alkyl)-NH—(C1-C5 alkyl),
• —O—(C1-C5 alkyl)-N—(C1-C5 alkyl)2,
• —O—(C1-C5 alkyl)-NH—SO2—(C1-C5 alkyl),
• —O—(C1-C5 alkyl)-N-pyrrolidin-2-one,
• —O—(C1-C5 alkyl)-N-pyrrolidine,
• —O—(C1-C5 alkyl)-(1-methylpyrrolidin-2-one-3-yl),
• —O—(C1-C5 alkyl)-SO2—(C1-C5 alkyl,)
• —O—(C1-C5 alkyl)-SO2—NH2,
• —O—(C1-C5 alkyl)-SO2—NH—(C1-C5 alkyl),
• —O—(C1-C5 alkyl)-SO2—N—(C1-C5 alkyl)2,
• —O—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —O—(C1-C5 alkyl)-S(O)—(C1-C5 alkyl,)
• —O—(C1-C5 alkyl)-S(O)—NH2,
• —O—(C1-C5 alkyl)-S(O)—NH—(C1-C5 alkyl),
• —O—(C1-C5 alkyl)-S(O)—N—(C1-C5 alkyl)2,
• —O—(C1-C5 alkyl)-S(O)—(C1-C5 alkyl),
• —O—(C1-C5 alkyl)-P(O)—(O—C1-C5 alkyl)2,
• —O—(C1-C5 alkyl)-5-tetrazolyl,
• —O—CH2—CO2H,
• —O—CH2-5-tetrazolyl,
• —O—(C1-C5 alkyl),
• —O—C(O)—NH2,
• —O—C(O)—N—(CH3)2,
• —O—C(S)—N—(CH3)2,
• —O—C(O)—O—(C1-C5 alkyl),
• —O-(5-tetrazolyl),
• —O—SO2—(C1-C5 alkyl,)
• —O—SO2—NH2,
• —O—SO2—NH—(C1-C5 alkyl),
• —O—SO2—N—(C1-C5 alkyl)2,
• —O—S(O)—(C1-C5 alkyl,)
• —O—S(O)—NH2,
• —O—S(O)—NH—(C1-C5 alkyl),
• —O—S(O)—N—(C1-C5 alkyl)2,
• —S—(C1-C5 alkyl),
• —S—(C2-C5 alkenyl),
• —S—(C3-C5 cycloalkyl),
• —S—(C3-C5 cycloalkenyl),
• —S—(C1-C5 fluoroalkyl),
• —S—(C1-C5 hydroxyalkyl),
• —S—(C1-C5 alkyl)-phenyl,
• —S—(C1-C5 alkyl)-O—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-C(O)—OH,
• —S—(C1-C5 alkyl)-C(O)—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-C(O)—O—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-C(O)—NH2,
• —S—(C1-C5 alkyl)-C(O)—NH—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-C(O)—N—(C1-C5 alkyl)2,
• —S—(C1-C5 alkyl) NH2,
• —S—(C1-C5 alkyl)-NH—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-N—(C1-C5 alkyl)2,
• —S—(C1-C5 alkyl)-NH—SO2—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-N-pyrrolidin-2-one,
• —S—(C1-C5 alkyl)-N-pyrrolidine,
• —S—(C1-C5 alkyl)-(1-methylpyrrolidin-2-one-3-yl),
• —S—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-SO2—NH2,
• —S—(C1-C5 alkyl)-SO2—NH—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-SO2—N—(C1-C5 alkyl)2,
• —S—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-P(O)—(O—C1-C5 alkyl)2,
• —S—(C1-C5 alkyl)-5-tetrazolyl,
• —S—(C1-C5 alkyl)-S(O)—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-S(O)—NH2,
• —S—(C1-C5 alkyl)-S(O)—NH—(C1-C5 alkyl),
• —S—(C1-C5 alkyl)-S(O)—N—(C1-C5 alkyl)2,
• —S—(C1-C5 alkyl)-S(O)—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl),
• —SO2—(C2-C5 alkenyl),
• —SO2—(C3-C5 cycloalkyl),
• —SO2—(C3-C5 cycloalkenyl),
• —SO2—(C1-C5 hydroxyalkyl),
• —SO2—(C1-C5 fluoroalkyl),
• —SO2-(C1-C5)-phenyl,
• —SO2—NH2,
• —SO2—NH—(C1-C5 alkyl),
• —SO2—NH—CH2—C(O)OH,
• —SO2—NH—CH2—C(O)(O—C1-C5 alkyl),
• —SO2—NH—(C1-C5 alkyl)-C(O)OH,
• —SO2—NH—(C1-C5 alkyl)-C(O)(O—C1-C5 alkyl),
• —SO2—NHC(O)—(C3-C6 cycloalkyl),
• —SO2—NH—C(O)—(C1-C5 alkyl),
• —SO2—N—(C1-C5 alkyl)2,
• —SO2—(C1-C5 alkyl)-O—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl)-C(O)—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl) NH2,
• —SO2—(C1-C5 alkyl)-NH—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl)-N—(C1-C5 alkyl)2,
• —SO2—(C1-C5 alkyl)-C(O)—NH2,
• —SO2—(C1-C5 alkyl)-C(O)—NH—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl)-C(O)—N—(C1-C5 alkyl)2,
• —SO2—(C1-C5 alkyl)-NH—SO2—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl)-N-pyrrolidin-2-one,
• —SO2—(C1-C5 alkyl)-N-pyrrolidine,
• —SO2—(C1-C5 alkyl)-(1-methylpyrrolidin-2-one-3-yl),
• —SO2—(C1-C5 alkyl)-C(O)—O—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl)-C(O)—OH,
• —SO2—(C1-C5 alkyl)-5-tetrazolyl,
• —SO2—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl)-SO2—NH2,
• —SO2—(C1-C5 alkyl)-SO2—NH—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl)-SO2—N—(C1-C5 alkyl)2,
• —SO2—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —SO2—(C1-C5 alkyl)-P(O)—(O—C1-C5 alkyl)2,
• —SO2—(C1-C5 alkyl),
• —SO2—(C2-C5 alkenyl),
• —SO2—(C3-C5 cycloalkyl),
• —SO2—(C3-C5 cycloalkenyl),
• —SO2—(C1-C5 hydroxyalkyl),
• —SO2—(C1-C5 fluoroalkyl),
• —SO2—(C1-C5)-phenyl,
• —SO2—N═CHN(C1-C5 alkyl)2,
• —S(O)—NH2,
• —S(O)—NH—(C1-C5 alkyl),
• —S(O)—NH—CH2—C(O)OH
• —S(O)—NH—(C1-C5 alkyl)-C(O)OH,
• —S(O)—NH—CH2—C(O)(O—C1-C5 alkyl),
• —S(O)—NH—(C1-C5 alkyl)-C(O)(O—C1-C5 alkyl),
• —S(O)HC(O)—(C3-C6 cycloalkyl),
• —S(O)—NH—C(O)—(C1-C5 alkyl),
• —S(O)—N—(C1-C5 alkyl)2,
• —S(O)—(C1-C5 alkyl)-O—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-C(O)—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-C(O)—(O—C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-NH—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-N—(C1-C5 alkyl)2,
• —S(O)—(C1-C5 alkyl)-C(O)—NH2,
• —S(O)—(C1-C5 alkyl)-C(O)—NH—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-C(O)—N—(C1-C5 alkyl)2,
• —S(O)—(C1-C5 alkyl)-NH—SO2—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-NH—S(O)—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-N-pyrrolidin-2-one,
• —S(O)—(C1-C5 alkyl)-N-pyrrolidine,
• —S(O)—(C1-C5 alkyl)-(1-methylpyrrolidin-2-one-3-yl),
• —S(O)—(C1-C5 alkyl)-C(O)—(O—C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-C(O)—OH,
• —S(O)—(C1-C5 alkyl)-5-tetrazolyl,
• —S(O)—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-S(O)—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-SO2—NH2,
• —S(O)—(C1-C5 alkyl)-S(O)—NH2,
• —S(O)—(C1-C5 alkyl)-SO2—NH—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-S(O)—NH—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-SO2—N—(C1-C5 alkyl)2,
• —S(O)—(C1-C5 alkyl)-S(O)—N—(C1-C5 alkyl)2,
• —S(O)—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-S(O)—(C1-C5 alkyl),
• —S(O)—(C1-C5 alkyl)-P(O)—(O—C1-C5 alkyl)2,
• —S(O)—N═CHN(C1-C5 alkyl)2,
• —NHC(S)NH2,
• —NHC(S)NH—(C1-C5 alkyl),
• —NHC(S)N—(C1-C5 alkyl)2,
• —NHC(S)NH—(C2-C5 alkenyl),
• —NHC(S)NH—(C3-C5 cycloalkyl),
• —NHC(S)NH—(C3-C5 cycloalkenyl),
• —NHC(S)NH—(C1-C5 fluoroalkyl),
• —NHC(S)NH—C1-C5 hydroxyalkyl,
• —NHC(S)NH—(C1-C5 fluoroalkyl)
• —NHC(S)NH-phenyl,
• —NHC(S)NH—(C1-C5 alkyl)-C(O)—OH,
• —NHC(S)NH—(C1-C5 alkyl)-O—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-C(O)—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-C(O)—(O—C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-NH2,
• —NHC(S)NH—(C1-C5 alkyl)-NH—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-N—(C1-C5 alkyl)2,
• —NHC(S)NH—(C1-C5 alkyl)-C(O)—NH2,
• —NHC(S)NH—(C1-C5 alkyl)-C(O)—NH—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-C(O)—N—(C1-C5 alkyl)2,
• —NHC(S)NH—(C1-C5 alkyl)-NH—SO2—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-NH—S(O)—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-N-pyrrolidin-2-one,
• —NHC(S)NH—(C1-C5 alkyl)-N-pyrrolidine,
• —NHC(S)NH—(C1-C5 alkyl)-(1-methylpyrrolidin-2-one-3-yl),
• —NHC(S)NH—(C1-C5 alkyl)-5-tetrazolyl,
• —NHC(S)NH—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-SO2—NH2,
• —NHC(S)NH—(C1-C5 alkyl)-SO2—NH—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-SO2—N—(C1-C5 alkyl)2,
• —NHC(S)NH—(C1-C5 alkyl)-S(O)—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-S(O)—NH2,
• —NHC(S)NH—(C1-C5 alkyl)-S(O)—NH—(C1-C5 alkyl),
• —NHC(S)NH—(C1-C5 alkyl)-S(O)—N—(C1-C5 alkyl)2,
• —NHC(S)NH—(C1-C5 alkyl)-P(O)—(O—C1-C5 alkyl)2,
• —NHC(O)NH2,
• —NHC(O)NH—(C1-C5 alkyl),
• —NHC(O)N—(C1-C5 alkyl)2,
• —NHC(O)NH—(C2-C5 alkenyl),
• —NHC(O)NH—(C3-C5 cycloalkyl),
• —NHC(O)NH—(C3-C5 cycloalkenyl),
• —NHC(O)NH—(C1-C5 hydroxyalkyl),
• —NHC(O)NH—(C1-C5 fluoroalkyl),
• —NHC(O)NH-phenyl,
• —NHC(O)NH—(C1-C5 alkyl)-NH2,
• —NHC(O)NH—(C1-C5 alkyl)-NH—(C1-C5 alkyl),
• —NHC(O)NH—(C1-C5 alkyl)-N—(C1-C5 alkyl)2,
• —NHC(O)NH—(C1-C5 alkyl)-O—(C1-C5 alkyl),
• —NHC(O)NH—(C1-C5 alkyl)-NH2,
• —NHC(O)NH—(C1-C5 alkyl)-NH—(C1-C5 alkyl),
• —NHC(O)NH—(C1-C5 alkyl)-N—(C1-C5 alkyl)2,
• —NHC(O)NH—(C1-C5 alkyl)-C(O)—NH2,
• —NHC(O)NH—(C1-C5 alkyl)-C(O)—NH—(C1-C5 alkyl),
• —NHC(O)NH—(C1-C5 alkyl)-C(O)—N—(C1-C5 alkyl)2,
• —NHC(O)NH—(C1-C5 alkyl)-C(O)—(C1-C5 alkyl),
• —NHC(O)NH—(C1-C5 alkyl)-NH—SO2—(C1-C5 alkyl),
• —NHC(O)NH—(C1-C5 alkyl)-N-pyrrolidin-2-one,
• —NHC(O)NH—(C1-C5 alkyl)-N-pyrrolidine,
• —NHC(O)NH—(C1-C5 alkyl)-(1-methylpyrrolidin-2-one-3-yl),
• —NHC(O)NH—(C1-C5 alkyl)-C(O)—OH,
• —NHC(O)NH—(C1-C5 alkyl)-C(O)—O—(C1-C5 alkyl),
• —NHC(O)NH—(C1-C5 alkyl)-5-tetrazolyl,
• —NHC(O)NH—(C1-C5 alkyl)-SO2—(C1-C5 alkyl),
• —NHC(O)NH—(C1-C5 alkyl)-SO2—NH2,
• —NHC(O)NH—(C1-C5 alkyl)-SO2—NH—(C1-C5 alkyl),
• —NHC(O)NH—(C1-C5 alkyl)-SO2—N—(C1-C5 alkyl)2,
• —NHC(O)NH—(C1-C5 alkyl)-P(O)—O—(C1-C5 alkyl)2,
• —NH2,
• —NH—(C1-C5 alkyl),
• —NH—CH2—C(O)OH,
• —N—(C1-C5 alkyl)2,
• —NH—C(O)—NH2,
• —NH—C(O)—NH—(C1-C5 alkyl),
• —NH—C(O)—N—(C1-C5 alkyl)2,
• —NH—C(O)—(C1-C5 alkyl),
• —NH—SO2—(C1-C5 alkyl),
• —NH—S(O)—(C1-C5 alkyl),
• —N(CH3)(OCH3),
• —N(OH)(CH3),
• —N-pyrrolidin-2-one,
• —N-pyrrolidine,
• -(1-methylpyrrolidin-2-one-3-yl),
• 1-hydroxycyclopentenyl,
• 1-hydroxycyclohexenyl,
• 1-hydroxycycloheptenyl,
• 1-hydroxycyclooctenyl,
• 1-hydroxycyclopropyl,
• 1-hydroxycyclobutyl,
• 1-hydroxycyclopentyl,
• 1-hydroxycyclohexyl,
• 1-hydroxycycloheptyl,
• 1-hydroxycyclooctyl,
• -5-tetrazolyl,
• -carboxyl,
• —OH,
• —I,
• —Br
• —Cl
• —F,
• —CHO,
• —NO2,
• —CN,
• sulfonamide,
• sulfinamide,
• urethane-type radical, or
• (Acidic Group);
• provided that the combined groups of formula I represented by
• may both be lipophilic, or either one may be lipophilic and the other one polar;
• but both combined groups may not be polar.