Narcistatin prodrugs
AssigneeArizona Board of Regents
InventorsGeorge Pettit, Noeleen Melody
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Abstract
The present invention provides prodrugs derived from the sparingly soluble anticancer isocarbostyril narciclasine, a component of various Narcissus species, said prodrugs having potential for use against animal and human cancers. Also disclosed is an efficient procedure for the synthetic conversion of narciclasine to several more soluble cyclic phosphate compounds, including “narcistatin”.
Claims4
A compound having the following structure:
- wherein Z is selected from the group consisting of pyridinium, H+, Li+, Na+, K+, Cs+, Mg2+, Ca2+, Zn2+, Mn2+, quinidine, quinine, imidazole, morpholine and piperazine.
A method for treating neoplastic disease comprising administering to a human subject a pharmaceutically acceptable amount of the following compound:
- wherein Z is selected from the group consisting of pyridinium, H+, Li+, Na+, K+, Cs+, Mg2+, Ca2+, Zn2+, Mn2+, quinidine, quinine, imidazole, morpholine and piperazine.
A method for treating cancer comprising administering to a human subject afflicted with cancer a pharmaceutically effective amount of the compound:
- wherein Z is selected from the group consisting of pyridinium, H+, Li+, Na+, K+, Cs+, Mg2+, Ca2+, Zn2+, Mn2+, quinidine, quinine, imidazole, morpholine and piperazine.
Dependencies are inferred from the claim text.