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US 2006/0135474 A1Published application
Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
AssigneeBristol-Myers Squibb Company
InventorsDaniel Benigni, Jack Gougoutas, John DiMarco
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Abstract
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
Claims9
A crystalline solvate comprising:
- a toluene-containing epothilone B clathrate.
Dependencies are inferred from the claim text.