Methods and compositions for the treatment of lupus using clofarabine
OwnerChristopher Wood, Stuart Smithinventors
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Abstract
This invention relates to methods of treating or preventing lupus comprising the administration of clofarabine or a pharmaceutically acceptable salt, hydrate, solvate or clathrate thereof to a patient in need of such treatment. The invention further relates to methods of treating or preventing lupus comprising the administration of clofarabine or a pharmaceutically acceptable salt, hydrate, solvate or clathrate thereof and an additional therapeutic agent to a patient in need of such treatment.
Claims19
A method of treating, preventing or managing lupus which comprises administering to a patient in need of such treatment a therapeutically or prophylactively effective amount of clofarabine or a pharmaceutically acceptable salt, stereoisomer, solvate, hydrate, clathrate, prodrug or metabolite thereof.
The method of claim 10 wherein the additional therapeutic agent is an antibiotic, an antiemetic agent, an antidepressant, and antifungal agent, an antiinflammatory agent, an antiviral agent, an immunomodulatory agent, an antimalarial agent, a β-interferon, an alkylating agent, a hormone or a cytokine.
A pharmaceutical composition for the treatment of lupus which comprises about 0.1 mg to about 1000 mg of clofarabine, or a pharmaceutically acceptable salt, hydrate, clathrate, solvate, prodrug, metabolite or stereoisomer thereof and a pharmaceutically acceptable carrier.
A pharmaceutical composition for treatment of lupus which comprises a therapeutically effective amount of clofarabine which sufficient to treat lupus for which is insufficent to case adverse affects associated with purine nucleosides.
A pharmaceutical composition for treatment of lupus which comprises a therapeutically effective amount of clofarabine and other immunomodulatory agent which sufficient to treat lupus for which is insufficent to case adverse affects associated with purine nucleosides.
Dependencies are inferred from the claim text.