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US 2006/0135460 A1Published application
Methods, assays and compositions for treating retinol-related diseases
AssigneeSytera, Inc.
InventorsKenneth Widder, Jay Lichter
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AssigneeSytera, Inc.
InventorsKenneth Widder, Jay Lichter
Estimating the term…
Described herein are methods and compositions for treating certain retinol-related diseases and conditions by modulation of transthyretin (TTR) and retinol binding protein (RBP) availability in the subject. For example, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-related macular degeneration and/or dystrophies, metabolic disorders, idiopathic intracranial hypertension, hyperostosis, and protein misfolding and aggregation diseases. The compositions disclosed may be used as single agent therapy or in combination with other agents or therapies. In addition, described herein are methods and assays for selecting appropriate agents that can modulate the TTR and RBP availability in a subject.
A method for treating retinol-related diseases in a mammal, comprising administering to the mammal at least once an effective amount of at least one of the compounds chosen from the group consisting of:
A method of treating age-related macular degeneration or dystrophy, comprising administering to a mammal at least once an effective amount of a first compound, wherein said first compound modulates RBP or TTR levels or activity in the mammal.
A method for treating type I or type II diabetes in a mammal, comprising administering to the mammal at least once an effective amount of a first compound, wherein said first compound modulates RBP or TTR levels or activity in the mammal.
Dependencies are inferred from the claim text.