Methods and compositions for the inhibition of gene expression
OwnerReza Sheikhnejad, Mina Sooch +2inventors
InventorsReza Sheikhnejad, Mina Sooch, Neal Goodwin, David Olson
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Abstract
The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.
Claims38
A composition comprising a first oligonucleotide that hybridizes under physiological conditions to the promoter region of a Her-2 gene.
A composition comprising an oligonucleotide that hybridizes to a promoter region of a Her-2 gene at a position selected from the group consisting of between nucleotides 205-344 of SEQ ID NO:29 and between nucleotides 382-435 of SEQ ID NO:29.
A method, comprising
- a) providing
- i) an oligonucleotide selected from the group consisting of SEQ ID NOs:
- 31, 32, 35, 36, 37, and 38;
- and
- ii) a cell comprising a Her-2 gene, wherein said Her-2 gene is capable of expression, and wherein said cell is capable of proliferation;
- and
- b) introducing said oligonucleotide to said cell.
A method, comprising
- a) providing
- i) an oligonucleotide that hybridizes to the promoter region of a Her-2 gene;
- and
- ii) a cell comprising a Her-2 gene;
- and
- b) introducing said oligonucleotide to said cell.
Dependencies are inferred from the claim text.