Methods for treating or preventing angiogenesis-dependent symptoms
AssigneeAnGes MG, Inc.
InventorsKazuya Hiraoka, Seiji Yamamoto, Yasufumi Kaneda, Ryuichi Morishita, Toshio Ogihara
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Abstract
A method for enhancing the transfection efficiency of naked plasmid DNA in treating and/or preventing angiogenesis-dependent symptoms is provided by the present inventions. According to the present method, a suitable naked plasmid DNA is subjected for intramuscular injection under increased pressure inside the muscle or hyperbaric oxygen. Angiogenesis-dependent symptoms, including wounds, inflammatory diseases, critical limb ischemia, ischemic heart diseases, cerebral infarction, diabetic neuropathy, spinal canal stenosis, etc., may be treated by the present methods.
Claims14
A method for treating or preventing an angiogenesis-dependent symptom comprising the step of injecting a naked plasmid DNA encoding an angiogenic growth factor into a muscle under a condition wherein the pressure inside the muscle is increased.
A method for treating or preventing angiogenesis-dependent symptom comprising the step of administering a naked plasmid DNA encoding an angiogenic growth factor into a muscle in combination with hyperbaric oxygen (HBO) therapy.
Dependencies are inferred from the claim text.