Combinations of antisense oligonucleotides directed against thymidylate synthase mrna and uses thereof

A pharmaceutical composition comprising a pharmaceutically acceptable carrier and:

• a) two or more antisense oligonucleotides complementary to a thymidylate synthase mRNA or analogues of said oligonucleotides;
• b) two or more antisense oligonucleotides complementary to different regions of a thymidylate synthase mRNA or analogues of said oligonucleotides;
• c) two or more antisense oligonucleotides or analogues thereof, wherein at least one of said antisense oligonucleotides or analogues thereof comprises at least 5 consecutive nucleotides selected from the nucleic acid sequences as set in forth in any one of SEQ ID NOs:
• 1, 2, 3, 5, 6 or 11;
• d) two or more antisense oligonucleotides or analogues thereof, wherein said antisense oligonucleotides or analogues thereof comprises at least 5 consecutive nucleotides selected from the nucleic acid sequences as set in forth in any one of SEQ ID NOs:
• 1, 2, 3, 5, 6 or 11;
• e) two or more antisense oligonucleotides or analogues of said oligonucleotides, wherein the sequences of two oligonucleotides of the combination are selected from SEQ ID NO:
• 1 and 2 or SEQ ID NO:
• 1 and 3;
• f) oligonucleotide analogues according to a), b), c), d) or e), wherein said analogues comprise one or more phosphorothioate linkages;
• or
• g) oligonucleotide analogues according to a), b), c), d), e) or f), wherein said analogues comprise one or more 2′-methoxy-ethoxy substituted nucleotide.