Hydroxypyridinones for the local treatment of skin microcirculatroy disorders
OwnerGhisalberti Carloinventor
Life of this patent
Estimating the term…
Abstract
The application of hydroxypyridonone in effective amounts as external agent for patients suffering from skin micro-circulatory disorders (SMD) provides for a significant amelioration of subject conditions. Accordingly, the new use of hydroxypyridonones as external anti-inflammatory agent thereby combined with the depletion of hemosiderin residues offers a suitable treatment to SMD sufferers.
Claims14
The use of a hydroxypyridonone of formulae (I-III):
- R1 represents a (C1-C10)-alkyl, (C1-C10)-alkenyl, (C1-C10)-alkoxy, (C1-C10)-hydroxyalkyl, (C5-C12)-aralkyl, (C3-C12)-cycloalkyl, (C1-C8)-carboalkoxy or (C1-C8)-carbamyl, or a (C10-C30)-peptide or peptidomimetic moiety, or a (C3-C6)-polyol or monosaccharide;
- R2 represents an hydrogen atom or a linear or branched, saturated or unsaturated (C1-C22)-acyl, optionally substituted by (C1-C8)-alkoxy, carboxy, (C1-C8)-alkoxycarbonyl, amino, hydroxy, said amino and hydroxy being optionally (C1-C22)-acylated or -alkylated;
- R3, R4 and R5, each individually, represent a hydrogen atom, or (C1-C10)-alkyl, (C1-C10)-alkenyl, (C1-C10)-alkoxy, (C5-C12 aryl) alkyl, (C5-C12)-cycloalkyl, (C1-C8 carbo)-alkoxy or (C1-C8)-carbamyl group;
- with the proviso that both R1 and R3 are not hydrogen;
- and dermatologically/cosmetically salts thereof.
- for the manufacture of a topical medicament useful in the treatment of a skin microcirculatory disorder (SMD).
Use according to claim 8, wherein the skin capillaritis is selected in the group consisting of progressive pigmentary dermatosis, purpura annularis telangiectodes, lichen aureus, contact allergy skin capillaritis, and lichens aureus. itching purpura, eczematid-like purpura, and pigmented purpuric lichenoid dermatosis.
Method according to claim 14, for the treatment of progressive pigmented purpura, itching purpura, pigmented purpuric lichenoid dermatosis, purpura annularis telangiectodes, contact allergy skin capillaritis, and lichens aureus.
Method according to claim 14, for the treatment of traumatic skin haemorrhage, complication of schlerotherapy, lipoplasty or tattooing, drug-induced pigmented purpuric dermatosis, and actinic purpura.
Dependencies are inferred from the claim text.