Peptides and methods for the control of obesity
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsCarrie Haskell-Luevano, Jerry Holder
Life of this patent
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Abstract
The subject invention provides novel peptides for use in treating mammals to control appetite and obesity. Disclosed is a peptide derivative having the formula: X1-Z-Q-arg-trp-NH2 wherein: X1 is an acyl group, Z is amino-2-naphthyl-carboxylic acid or histidine, Q is (D)phenylalanine or p-iodo-(D)phenylalanine, or a pharmacologically acceptable salt, complex or derivative thereof, the peptide derivative having melanocortin-4 receptor agonist activity.
Claims10
A peptide derivative having the formula:X.sup.1-Z-Q-arg-trp-NH.sub.2wherein:
- X.sup.1 is an acyl group, Z is amino-2-naphthyl-carboxylic acid or histidine, Q is (D)phenylalanine or p-iodo-(D)phenylalanine, or a pharmacologically acceptable salt, complex or derivative thereof, said peptide derivative having melanocortin-4 receptor agonist activity.
The peptide derivative according to claim, 1 wherein Z is histidine.
Dependencies are inferred from the claim text.