Compositions and methods for inducing apoptosis in tumor cells
AssigneeE-P Therapeutics, Inc.
InventorsThomas Chen, Maria Chen
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Abstract
A method is described for using an E-domain peptide for the induction of apoptosis in a cancer cells. In particular, the invention relates to methods for using a-type E-domain peptide from trout IGF and/or a b-type E-domain peptide from human IGF for the induction of apoptosis in a broad spectrum of cancer cells. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more cancer cells alone or in a pharmaceutically acceptable composition.
Claims23
A method for inducing apoptosis in a cancer cell, comprising administering an effective amount to one or more cancer cells of at least one of an E-domain insulin-like growth factor (IGF-1) peptide composition selected from the group consisting of an Ea4-domain peptide having the amino acid sequence of SEQ ID NO:2, an hEb domain having the amino acid sequence of SEQ ID NO:1, and combinations thereof.
A method for treating cancer in an animal tissue comprising, providing an animal in need thereof, and administering an effective amount of at least one of an E-domain insulin-like growth factor (IGF-1) peptide composition selected from the group consisting of an Ea-4 domain peptide having the amino acid sequence of SEQ ID NO:2, an hEb domain having the amino acid sequence of SEQ ID NO:1, and combinations thereof, and wherein the E-domain peptide induces apoptosis in a cancer cell.
Dependencies are inferred from the claim text.