Proteins involved in the regulation of energy homeostasis
AssigneeDeveloGen Aktiengesellschaft fuer entwick- lungsbiologische Forschung
Inventorsf Meise, Karsten Eulenberg, Tri Nguyen, Theodoros Tsetsenis
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Abstract
The prevent invention discloses PRL-1 homologous proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of metabolic diseases and disorders.
Claims37
A pharmaceutical composition comprising a PRL-1 homologous protein or/and a functional fragment thereof, a nucleic acid molecule encoding a PRL-1 homologous protein or/and a functional fragment thereof or/and a modulator/effector of said nucleic acid molecule or/and protein together with pharmaceutically acceptable carriers, diluents or/and additives.
Use of a PRL-1 homologous nucleic acid molecule or/and of a functional fragment thereof for the production of a non-human transgenic animal which over- or under-expresses the PRL-1 homologous gene product.
Kit comprising at least one of
- (a) a PRL-1 homolgous nucleic acid molecule or/and a functional fragment thereof;
- (b) a PRL-1 homologous amino acid molecule or/and a functional fragment or/and an isoform thereof;
- (c) a vector comprising the nucleic acid of (a);
- (d) a host cell comprising the nucleic acid of (a) or the vector of (c);
- (e) a polypeptide encoded by the nucleic acid of (a);
- (f) a fusion polypeptide encoded by the nucleic acid of (a);
- (g) an antibody, an aptamer or/and another modulator/effector of the nucleic acid of (a) or the polypeptide of (b), (e), or/and (f) and
- (h) an anti-sense oligonucleotide of the nucleic acid of (a).
Dependencies are inferred from the claim text.