Multifunctional context-activated protides and methods of use
AssigneeMichael Yeaman
InventorsMichael Yeaman, Nanette Yount, John Edwards Jr., Eric Brass
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Abstract
This invention is directed to multifunctional, context-activated protides that have two or more effectors with individually distinct biological functions and one or more corresponding activator sites that can each initiate or amplify the biological function of one or more effectors upon context-activation. The context-activated protides of the invention are useful in the diagnosis, prophylaxis, and therapy of a broad range of pathological conditions.
Claims73
A context-activated protide comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 1, 2, 3 and 4.
A context-activated protide consisting of the amino acid sequence selected from the group consisting of SEQ ID NOS:
- 1, 2, 3 and 4.
A context-activated protide comprising at least one activator site and two or more effectors, wherein at least two of said effectors have distinct biological functions.
The protide of claim 30, wherein said activator activates a cytokine effector.
The protide of claim 31, wherein said effector is Interleukin-8.
A context-activated protide comprising one activator site and two effector peptides having distinct biological functions, wherein said distinct biological functions are antimicrobial and immunomodulatory.
A context-activated protide comprising one activator site and two effector peptides having distinct biological functions, wherein said distinct biological functions are anti-toxic and antimicrobial.
A context-activated protide comprising one activator site and two effector peptides having distinct biological functions, wherein said distinct biological functions are anti-angiogenic and antimicrobial.
A context-activated protide comprising one activator site and two effector peptides having distinct biological functions, wherein said distinct biological functions are pro-apoptotic and anti-angiogenic.
Dependencies are inferred from the claim text.