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OwnerPatrick Silcock, Lynton Bridger +3inventors
InventorsPatrick Silcock, Lynton Bridger, Adrian Kerr, Martin Ferguson, Jean-Pierre Ghislain Dufour
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The invention provides, in one aspect, compositions for delivering a bioactive metal ion to a mammal, the compositions comprising (a) an effective amount of a source of the bioactive metal ion, (b) a phosphoprotein preparation obtained by partially cross linking a partial hydrolysate of casein or a caseinate, and (c) one or more physiologically acceptable diluents or carriers. Also provided are compositions for remineralising tooth enamel and/or for treating or preventing dental caries, tooth erosion, dentinal hypersensitivity or gingivitis in a mammal, wherein the compositions comprise an effective amount of such a phosphoprotein preparation, in combination with one or more carriers or diluents. In related aspects, the invention provides methods of using such compositions. Also provided are novel phosphoprotein preparations suitable for use in such compositions and methods.
A composition for delivering a bioactive metal ion to a mammal, the composition comprising an effective amount of a source of the bioactive metal ion, a phosphoprotein preparation obtained by partially cross linking a partial hydrolysate of casein or a caseinate, and one or more physiologically acceptable diluents or carriers.
A composition for remineralizing tooth enamel and/or for treating or preventing one or more conditions selected from the group consisting of dental caries, tooth erosion, dentinal hypersensitivity and gingivitis in a mammal, wherein the composition comprises an effective amount of a phosphoprotein preparation in combination with one or more carriers or diluents, wherein the phosphoprotein preparation has been obtained by partially cross linking a partial hydrolysate of casein or a caseinate.
A phosphoprotein preparation, which has been obtained by partially cross linking a partial hydrolysate of casein or a caseinate, and wherein the degree of partial hydrolysis of the casein or case mate prior to cross linking is in the range of about 3% to about 8% of the total number of peptide bonds, and the degree of partial cross linking is such that the phosphoprotein preparation comprises about 10 or more μmol cross links per gram of protein.
Dependencies are inferred from the claim text.