Water soluble paclitaxel derivatives
AssigneeCell Therapeutics, Inc.
InventorsChun Li, Sidney Wallace, Dong-Fang Yu, David Yang
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Abstract
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
Claims11
A composition comprising (i) a conjugate of a therapeutic agent, contrast agent or drug and (ii) a water-soluble amino acid polymer in which there is more than one different type of amino acid residue and in which greater than 50% of the amino acid residues comprise glutamic acid and/or aspartic acid and/or lysine.
A water soluble amino acid chain or polymer comprising a mixture of glutamic acid, aspartic acid, and/or lysine having about 25%, about 26%, about 27%, about 28%, about 29%, about 30%, about 31%, about 32%, about 33%, about 34%, about 35%, about 36%, about 37%, about 38%, about 39%, about 40%, about 41%, about 42%, about 43%, about 44%, about 45%, about 46%, about 47%, about 48%, about 49%, to about 50% or so of the glutamic acid, aspartic acid, or lysine residues, respectively, substituted by any of the naturally occurring amino acids such that the majority of residues comprise glutamic acid and/or aspartic acid and/or lysine.
Dependencies are inferred from the claim text.