Purification of immunoglobulins
AssigneeGE Healthcare Bio-Sciences AB
InventorsHans Berg, Gunnar Malmquist, Per-Mikael Aberg, Hans Johansson
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Abstract
The present invention relates to a separation matrix comprised of porous particles to which antibody-binding protein ligands have been immobilised, wherein the ligand density is in the range of 5.0-10 mg/ml; the gel phase distribution coefficient of the particles expressed as Kav for a dextran of size 110 kDa is above 0.65 and the median particle diameter is between 65-84 μm. The carbohydrate material is preferably highly cross-linked agarose.
Claims26
A separation matrix comprising porous carbohydrate particles and antibody-binding protein ligands immobilised thereon, wherein the ligand density is in the range of 5.0-10 mg/ml;
- the gel phase distribution coefficient expressed as Kav for a dextran of size 110 kDa is above 0.65 and the median particle diameter is in the range of 65-84 μm.
Dependencies are inferred from the claim text.