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US 2006/0134796 A1Published application
Colorimetric sensors constructed of diacetylene materials
Assignee3M Innovative Properties Company
InventorsG. Bommarito, Brinda Lakshmi
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Abstract
Colorimetric sensors for detection of an analyte are disclosed. Methods of using the colorimetric sensor and a kit for the colorimetric detection of an analyte are also disclosed.
Claims20
A colorimetric system for detecting an analyte, comprising:
- a colorimetric sensor comprising:
- a receptor;
- a polymerized composition comprising at least one diacetylene compound;
- wherein the receptor is incorporated into the polymerized composition to form a transducer;
- and
- a buffer composition that mediates the interaction between the analyte and the transducer;
- wherein the transducer exhibits a color change when contacted with an analyte;
- and further wherein wherein the diacetylene compound has the following formula prior to polymerization:
- R3, R8, R13, R21, R24, R31, and R33 are independently C1-C20 alkyl;
- R4, R5, R7, R14 , R16, R19, R20, R22, R25, and R32 independently C1-C14 alkylene;
- R6, R15, R18, and R26 are independently C1-C14 alkylene, C2-C8 alkenylene, or C6-C13 arylene;
- R9 is C1-C14 alkylene or —NR34—;
- R10, R12, R27, and R29 are independently C1-C14 alkylene or (C1-C14 alkylene)-(C2-C8 arylene);
- R11 and R28 are independently C2-C30 alkynyl;
- R17 is an ester-activating group;
- R23 is C6-C13 arylene;
- R30 is C1-C14 alkylene or —NR36—;
- R34 and R36 are C1-C4 alkyl;
- p is 1-5;
- and
- n is 1-20;
- wherein R1 and R2 are not the same.
19 more elements
A method for the detection of an analyte, comprising:
- forming a colorimetric sensor, comprising a receptor and a polymerized composition comprising a diacetylene, wherein the receptor is incorporated into the polymerized composition to form a transducer capable of exhibiting a color change;
- contacting the sensor with a probe;
- further contacting the sensor with a sample suspected of containing a target analyte in the presence of a buffer composition;
- and
- observing a color change if the analyte is present;
- wherein wherein the diacetylene compound has the following formula prior to polymerization:
- R3, R8, R13, R21, R24, R31, and R33 are independently C1-C20 alkyl;
- R4, R5, R7, R14, R16, R19, R20, R22, R25, and R32 are independently C1-C14 alkylene;
- R6, R15, R18, and R26 are independently C1-C14 alkylene, C2-C8 alkenylene, or C6-C13 arylene;
- R9 is C1-C14 alkylene or —NR34—;
- R10, R12, R27, and R29 are independently C1-C14 alkylene or (C1-C14 alkylene)-( C2-C8 arylene);
- R11 and R28 are independently C2-C30 alkynyl;
- R17 is an ester-activating group;
- R23 is C6-C13 arylene;
- R30 is C1-C14 alkylene or —NR36—;
- R34 and R36 are C1-C4 alkyl;
- p is 1-5;
- and
- n is 1-20;
- wherein R1 and R2 are not the same.
17 more elements
A method for the detection of an analyte, comprising:
- forming a colorimetric sensor, comprising a receptor and a polymerized composition comprising a diacetylene, wherein the receptor is incorporated into the polymerized composition to form a transducer capable of exhibiting a color change in the presence of a probe;
- contacting the transducer with a sample suspected of containing a target analyte, and a probe that has an affinity for both the target analyte and the receptor in the presence of a buffer composition;
- and
- observing essentially no color change if the analyte is present;
- wherein the diacetylene compound has the following formula prior to polymerization:
- R3, R8, R13, R21, R24, R31, and R33 are independently C1-C20 alkyl;
- R4, R5, R7, R14, R16, R19, R20, R22, R25, and R32 are independently C1-C14 alkylene;
- R6, R15, R18, and R26 are independently C1-C14 alkylene, C2-C8 alkenylene, or C6-C13 arylene;
- R9 is C1-C14 alkylene or —NR34—;
- R10, R12, R27, and R29 are independently C1-C14 alkylene or (C1-C14 alkylene)-(C2-C8 arylene);
- R11 and R28 are independently C2-C30 alkynyl;
- R17 is an ester-activating group;
- R23 is C6-C13 arylene;
- R30 is C1-C14 alkylene or —NR36—;
- R34 and R36 are C1-C4 alkyl;
- p is 1-5;
- and
- n is 1-20;
- wherein R1 and R2 are not the same.
16 more elements
Dependencies are inferred from the claim text.