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US 2006/0134791 A1Published application
Compositions and methods for activating genes of interest
OwnerCharles Blackinventor
Life of this patent
Estimating the term…
Abstract
Compositions and methods for activating genes of interest are provided. The compositions comprise a masked targeted expression cassette which expresses a gene product only in the presence of a target molecule. The cassettes are useful for the treatment of disease and for preventing the proliferation of neoplastic cells.
Claims5
1-3. (canceled)
A masked expression cassette comprising a double stranded nucleic acid molecule comprising a first strand comprising a 5′ sense sequence and a 3′ sense sequence;
- said first strand further comprising an RNA sequence which codes for a protein of interest linked downstream of said 5′ sense sequence, and a translation initiation site operably inserted upstream of the RNA sequence;
- and,
- a second strand bound to said 5′ sense sequence and to said 3′ sense sequence, wherein said second strand comprises a polynucleotide corresponding to said 5′ sense sequence and to said 3′ sense sequence and to a target molecule.
7-12. (canceled)
Dependencies are inferred from the claim text.