Methods of expanding myeloid cell populations and uses thereof
AssigneeCellerant Therapeutics, Inc.
InventorsTimothy Fong, Adrianus Geertrudis Domen, Julie Christensen
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Abstract
The present disclosure relates to a method of expanding myeloid progenitor cells by culturing an initial population of cells in a medium comprising a mixture of cytokines and growth factors that promote growth and expansion of the myeloid progenitor cells. The expanded cell population provides a source of cells as therapeutic treatments for neutropenia and/or thrombocytopenia arising in patients subjected to myeloablative therapy and hematopoietic stem cell transplantation.
Claims49
A method of preparing a therapeutic composition for transiently reconstituting hematopoiesis in a mammalian host, comprising:
- a) culturing a starting cell population including hematopoietic stem cells ex vivo in a culture medium comprising a cytokine and growth factor mixture to expand the myeloid progenitor cells within said cell population;
- and b) resuspending said myeloid progenitor cells in a pharmaceutically acceptable medium suitable for administration to a mammalian host.
A therapeutic composition comprising ex vivo expanded myeloid progenitor cells, wherein said myeloid progenitor cells are a mixture of allogeneic myeloid progenitor cells.
Dependencies are inferred from the claim text.