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US 2006/0134769 A1Published application
Process for producing a virus-inactivated thrombin preparation
AssigneeBio Products Laboratory Limited
InventorsCaroline Connolly, Christopher Hardway, David Evans, Peter Feldman
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Abstract
The present invention relates to processes for the preparation of virus inactivated thrombin, and to the products prepared by these processes.
Claims15
A method for the preparation of virus-inactivated thrombin comprising the steps of:
- (a) solvent-detergent virus inactivating of a solution comprising prothrombin and factor X;
- (b) loading the product of step (a) onto an anion exchange medium;
- (c) washing the anion exchange medium to remove reagents used for the solvent-detergent virus inactivating in step (a);
- and
- (d) activating the prothrombin on the anion exchange medium to form thrombin by addition of metal ions.
2 more elements
A method for the preparation of virus-inactivated thrombin comprising the steps of:
- (a) solvent-detergent virus inactivating of a solution comprising factor X;
- (b) loading the product of step (a) onto an anion exchange medium;
- (c) washing the anion exchange medium to remove reagents used for the solvent-detergent virus inactivating in step (a);
- (d) activating the factor X on the anion exchange medium to form factor Xa by addition of metal ions;
- and
- (e) loading virus-inactivated prothrombin onto the anion exchange medium such that thrombin is generated.
3 more elements
The method according to 1 or 3, wherein steps (a) and (b) are replaced by steps (a′) and (b′):
- (a′) loading a solution comprising prothrombin and factor X onto an anion exchange medium;
- and
- (b′) solvent-detergent virus inactivating of the prothrombin and factor X on the anion exchange medium.
canceled
Dependencies are inferred from the claim text.