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US 2006/0134719 A1Published application
Novel serine protease
OwnerMasayoshi Takeda, Noboru Yamajiinventors
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OwnerMasayoshi Takeda, Noboru Yamajiinventors
Estimating the term…
It is disclosed that a novel polypeptide useful for screening for an agent for specific diseases to which gastrointestinal hormones are related, particularly irritable bowel syndrome, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, and a transfected cell by the vector. It is disclosed that the polypeptide is a novel type II transmembrane serine protease related to the regulation of hormones produced in gastrointestinal tract or a precursor thereof. Additionally, a screening method of an agent for gastrointestinal diseases using the polypeptide and a method for producing a pharmaceutical composition for the treatment of gastrointestinal diseases, comprising a substance obtained by the screening method as the active ingredient are disclosed.
A polypeptide which comprises the 237th to 531st amino acid sequence in the amino acid sequence represented by SEQ ID NO:2 and is an enzyme which shows a protease activity.
A polypeptide consisting of the 237th to 531st amino acid sequence in the amino acid sequence represented by SEQ ID NO:2.
A polypeptide which comprises the 51st to 531st amino acid sequence in the amino acid sequence represented by SEQ ID NO:2 and is a precursor of an enzyme which shows a protease activity.
A polypeptide which comprises an amino acid sequence in which the 51st to 531st amino acid sequence in the amino acid sequence represented by SEQ ID NO:2 is conjugated to the C-terminus side of
A polypeptide consisting of an amino acid sequence represented by SEQ ID NO:2, or
Dependencies are inferred from the claim text.