Sulfotransferase sequence variants
AssigneeMayo Foundation for Medical Education and Research, a Minnesota corporation
InventorsRobert Freimuth, Eric Wieben, Richard Weinshilboum
Life of this patent
Estimating the term…
Abstract
Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to thyroid disease or cancer also are described.
Claims16
A method for determining if a mammal is predisposed to a thyroid disease, wherein said method comprises:
- a) providing a biological sample from said mammal, and
- b) detecting the presence or absence of a SULT1C1 nucleotide sequence variant in said sample, wherein predisposition to a thyroid disease is determined based on the presence or absence of said variant.
A method for determining if a mammal is predisposed to cancer, wherein said method comprises:
- a) providing a biological sample from said mammal, and
- b) detecting the presence or absence of a SULT1C1 nucleotide sequence variant in said sample, wherein predisposition to cancer is determined based on the presence or absence of said variant.
A method for obtaining a SULT1C1 variant profile, wherein said method comprises:
- a) providing a biological sample from a mammal, and
- b) detecting the presence or absence of a plurality of SULT1C1 nucleotide sequence variants in said sample to obtain a variant profile of said mammal.
A method for determining the sulfonator status of a subject, said method comprising determining whether said subject comprises a variant SULT1C1 nucleic acid.
Dependencies are inferred from the claim text.