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US 2006/0134676 A1Published application
Methods for drug discovery, disease treatment, and diagnosis using metabolomics
AssigneesCornell Research Foundation, Inc., Metabolon, Inc.
InventorsRima Kaddurah-Daouk, Bruce Kristal
Life of this patent
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Abstract
The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.
Claims11
A method for identifying small molecules relevant to depression, comprising:
- obtaining a small molecule profile of a subject suffering from depression;
- and
- comparing the small molecule profile to a standard small molecule profile;
- thereby identifying the small molecules relevant to depression.
1 more element
A method for metabolomically monitoring the effectiveness of a therapeutic agent for depression in a clinical trial, comprising:
- obtaining a small molecule profile from a subject in a clinical trial being treated with a therapeutic agent;
- and
- monitoring changes in the small molecule profile of the subject as in indication of the effectiveness of the therapeutic agent in the subject, thereby monitoring the effectiveness of said therapeutic agent.
Dependencies are inferred from the claim text.